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学科主题: 药学
题名:
Photosensitive Cross-linked Block Copolymers with Controllable Release
作者: Yu, LiLi1,2; Lv, Cong1; Wu, LiZhu3; Tung, ChenHo3; Lv, WanLiang1; Li, ZhongJin2; Tang, XinJing1
刊名: PHOTOCHEMISTRY AND PHOTOBIOLOGY
发表日期: 2011-05-01
DOI: 10.1111/j.1751-1097.2011.00894.x
卷: 87, 期:3, 页:646-652
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ACID-DEGRADABLE PARTICLES ; PROTEIN-BASED VACCINES ; DRUG-DELIVERY SYSTEMS ; HYDROLYTIC DEGRADATION ; VESICLE FORMATION ; POLYMER MICELLES ; LIGHT ; NANOPARTICLES ; SURFACTANT ; ORGANIZATION
英文摘要:

We intend to form photosensitive block copolymer micelles for controllable release of encapsulated substances. Here, we designed and synthesized a new photocleavable cross-linker (2-nitrophenyl ethylene glycol dimethacrylate) for methyl methacrylate (MMA) atom transfer radical polymerization. Four different ratios (0:1, 1:26, 1:16, 1:8.8) of the photocleavable cross-linker to MMA monomer were used and four block copolymers (P0, P1, P2, P3) were synthesized with PEO-Br as the macroinitiator. Gel permeation chromatography and (1)H NMR studies showed that linear polymer molecules could be cross-linked by the photocleavable linker. The fluorescence studies of the encapsulated Nile Red (NR) showed that there were lower critical micelle concentrations for the polymer P1, P2 and P3 than polymer P0. And dynamic light scattering and SEM confirmed the formation of polymer micelles. Photolysis experiments demonstrated that NR encapsulated in the polymer micelles could be released upon UV irradiation (365 nm, 11 mW cm(-2)) due to the breakage of the photocleavable linker and the generation of more hydrophilic acid moieties, which destabilized polymer micelles. Our study shows a new strategy for the possibility of photocontrollable drug release for hydrophobic drugs.

语种: 英语
所属项目编号: 20090101 ; 21072015 ; 20100001120051
项目资助者: Peking University ; National Science Foundation of China ; Ministry of Education
WOS记录号: WOS:000289774200020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51548
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Shaanxi Univ Sci & Technol, Minist Educ, Key Lab Auxiliary Chem & Technol Chem Ind, Xian, Shaanxi, Peoples R China
3.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing, Peoples R China

Recommended Citation:
Yu, LiLi,Lv, Cong,Wu, LiZhu,et al. Photosensitive Cross-linked Block Copolymers with Controllable Release[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY,2011,87(3):646-652.
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