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Photosensitive Cross-linked Block Copolymers with Controllable Release
Yu, LiLi1,2; Lv, Cong1; Wu, LiZhu3; Tung, ChenHo3; Lv, WanLiang1; Li, ZhongJin2; Tang, XinJing1
刊名PHOTOCHEMISTRY AND PHOTOBIOLOGY
2011-05-01
DOI10.1111/j.1751-1097.2011.00894.x
87期:3页:646-652
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者Peking University ; National Science Foundation of China ; Ministry of Education ; Peking University ; National Science Foundation of China ; Ministry of Education
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ACID-DEGRADABLE PARTICLES ; PROTEIN-BASED VACCINES ; DRUG-DELIVERY SYSTEMS ; HYDROLYTIC DEGRADATION ; VESICLE FORMATION ; POLYMER MICELLES ; LIGHT ; NANOPARTICLES ; SURFACTANT ; ORGANIZATION
英文摘要

We intend to form photosensitive block copolymer micelles for controllable release of encapsulated substances. Here, we designed and synthesized a new photocleavable cross-linker (2-nitrophenyl ethylene glycol dimethacrylate) for methyl methacrylate (MMA) atom transfer radical polymerization. Four different ratios (0:1, 1:26, 1:16, 1:8.8) of the photocleavable cross-linker to MMA monomer were used and four block copolymers (P0, P1, P2, P3) were synthesized with PEO-Br as the macroinitiator. Gel permeation chromatography and (1)H NMR studies showed that linear polymer molecules could be cross-linked by the photocleavable linker. The fluorescence studies of the encapsulated Nile Red (NR) showed that there were lower critical micelle concentrations for the polymer P1, P2 and P3 than polymer P0. And dynamic light scattering and SEM confirmed the formation of polymer micelles. Photolysis experiments demonstrated that NR encapsulated in the polymer micelles could be released upon UV irradiation (365 nm, 11 mW cm(-2)) due to the breakage of the photocleavable linker and the generation of more hydrophilic acid moieties, which destabilized polymer micelles. Our study shows a new strategy for the possibility of photocontrollable drug release for hydrophobic drugs.

语种英语
所属项目编号20090101 ; 21072015 ; 20100001120051
资助者Peking University ; National Science Foundation of China ; Ministry of Education ; Peking University ; National Science Foundation of China ; Ministry of Education
WOS记录号WOS:000289774200020
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51548
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Shaanxi Univ Sci & Technol, Minist Educ, Key Lab Auxiliary Chem & Technol Chem Ind, Xian, Shaanxi, Peoples R China
3.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yu, LiLi,Lv, Cong,Wu, LiZhu,et al. Photosensitive Cross-linked Block Copolymers with Controllable Release[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY,2011,87(3):646-652.
APA Yu, LiLi.,Lv, Cong.,Wu, LiZhu.,Tung, ChenHo.,Lv, WanLiang.,...&Tang, XinJing.(2011).Photosensitive Cross-linked Block Copolymers with Controllable Release.PHOTOCHEMISTRY AND PHOTOBIOLOGY,87(3),646-652.
MLA Yu, LiLi,et al."Photosensitive Cross-linked Block Copolymers with Controllable Release".PHOTOCHEMISTRY AND PHOTOBIOLOGY 87.3(2011):646-652.
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