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Effects of cannabinoid CB1 receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice
Yu, Lu-Lu1,2,3; Zhou, Shuang-Jiang1,2,3; Wang, Xue-Yi1,2,3; Liu, Jian-Feng4; Xue, Yan-Xue4; Jiang, Wengao4; Lu, Lin4
关键词Rimonabant Cannabinoid Cb1 Receptors Acquisition Reinstatement Psychostimulant Conditioned Place Preference
刊名BEHAVIOURAL BRAIN RESEARCH
2011-02-02
DOI10.1016/j.bbr.2010.10.008
217期:1页:111-116
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]CONDITIONED PLACE PREFERENCE ; VENTRAL TEGMENTAL AREA ; ENDOCANNABINOID SYSTEM ; DRUG-ADDICTION ; MOLECULAR-MECHANISMS ; BASOLATERAL AMYGDALA ; KNOCKOUT MICE ; COCAINE ; RATS ; CONSOLIDATION
英文摘要

Drug addiction processes are considered to be mainly controlled by the mesocorticolimbic dopamine system. Cannabinoids, a class of psychoactive drugs of abuse, elicit their rewarding and pharmacological effects through the endocannabinoid system. Previous research has indicated that dopaminergic neurons in the mesocorticolimbic system are also under the control of the endocannabinoid system. Recently, evidence has suggested that the endocannabinoid system may also participate in the modulation of the common reward system. The present study examined whether rimonabant, a cannabinoid CBI receptor antagonist, disrupts the acquisition and reinstatement of psychostimulant reward memory measured by conditioned place preference (CPP). Mice were trained to acquire methamphetamine or cocaine-induced CPP. A priming injection of methamphetamine (0.5 mg/kg, i.p.) or cocaine (5 mg/kg, i.p.) was respectively given to reinstate methamphetamine or cocaine-induced CPP after extinction. Vehicle or rimonabant (1 or 3 mg/kg, i.p.) was administered at different time-points: 30 min before each CPP training session (acquisition) or 30 min before the priming injection (reinstatement). Rimonabant at doses of 1 and 3 mg/kg significantly inhibited the acquisition of methamphetamine- and cocaine-induced CPP. At the high dose (3 mg/kg), rimonabant disrupted the reinstatement of extinguished methamphetamine- or cocaine-induced CPP. These findings indicate that cannabinoid CBI receptors play a major role in psychostimulant reward memory, and rimonabant may be a potential pharmacotherapy for psychostimulant addiction. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000286539700016
项目编号2009CB522004 ; 31070958
资助机构National Basic Research Program of China ; Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51553
专题中国药物依赖性研究所
作者单位1.Hebei Med Univ, Hosp 1, Shijiazhuang 050031, Peoples R China
2.Hebei Med Univ, Inst Mental Hlth, Shijiazhuang 050031, Peoples R China
3.Hebei Med Univ, Hebei Brain Ageing & Cognit Neurosci Lab, Shijiazhuang 050031, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
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Yu, Lu-Lu,Zhou, Shuang-Jiang,Wang, Xue-Yi,et al. Effects of cannabinoid CB1 receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice[J]. BEHAVIOURAL BRAIN RESEARCH,2011,217(1):111-116.
APA Yu, Lu-Lu.,Zhou, Shuang-Jiang.,Wang, Xue-Yi.,Liu, Jian-Feng.,Xue, Yan-Xue.,...&Lu, Lin.(2011).Effects of cannabinoid CB1 receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice.BEHAVIOURAL BRAIN RESEARCH,217(1),111-116.
MLA Yu, Lu-Lu,et al."Effects of cannabinoid CB1 receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice".BEHAVIOURAL BRAIN RESEARCH 217.1(2011):111-116.
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