北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Effects of cannabinoid CB1 receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice
作者: Yu, Lu-Lu1,2,3; Zhou, Shuang-Jiang1,2,3; Wang, Xue-Yi1,2,3; Liu, Jian-Feng4; Xue, Yan-Xue4; Jiang, Wengao4; Lu, Lin4
关键词: Rimonabant ; Cannabinoid CB1 receptors ; Acquisition ; Reinstatement ; Psychostimulant ; Conditioned place preference
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2011-02-02
DOI: 10.1016/j.bbr.2010.10.008
卷: 217, 期:1, 页:111-116
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; VENTRAL TEGMENTAL AREA ; ENDOCANNABINOID SYSTEM ; DRUG-ADDICTION ; MOLECULAR-MECHANISMS ; BASOLATERAL AMYGDALA ; KNOCKOUT MICE ; COCAINE ; RATS ; CONSOLIDATION
英文摘要:

Drug addiction processes are considered to be mainly controlled by the mesocorticolimbic dopamine system. Cannabinoids, a class of psychoactive drugs of abuse, elicit their rewarding and pharmacological effects through the endocannabinoid system. Previous research has indicated that dopaminergic neurons in the mesocorticolimbic system are also under the control of the endocannabinoid system. Recently, evidence has suggested that the endocannabinoid system may also participate in the modulation of the common reward system. The present study examined whether rimonabant, a cannabinoid CBI receptor antagonist, disrupts the acquisition and reinstatement of psychostimulant reward memory measured by conditioned place preference (CPP). Mice were trained to acquire methamphetamine or cocaine-induced CPP. A priming injection of methamphetamine (0.5 mg/kg, i.p.) or cocaine (5 mg/kg, i.p.) was respectively given to reinstate methamphetamine or cocaine-induced CPP after extinction. Vehicle or rimonabant (1 or 3 mg/kg, i.p.) was administered at different time-points: 30 min before each CPP training session (acquisition) or 30 min before the priming injection (reinstatement). Rimonabant at doses of 1 and 3 mg/kg significantly inhibited the acquisition of methamphetamine- and cocaine-induced CPP. At the high dose (3 mg/kg), rimonabant disrupted the reinstatement of extinguished methamphetamine- or cocaine-induced CPP. These findings indicate that cannabinoid CBI receptors play a major role in psychostimulant reward memory, and rimonabant may be a potential pharmacotherapy for psychostimulant addiction. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB522004 ; 31070958
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China
WOS记录号: WOS:000286539700016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51553
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Hebei Med Univ, Hosp 1, Shijiazhuang 050031, Peoples R China
2.Hebei Med Univ, Inst Mental Hlth, Shijiazhuang 050031, Peoples R China
3.Hebei Med Univ, Hebei Brain Ageing & Cognit Neurosci Lab, Shijiazhuang 050031, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Yu, Lu-Lu,Zhou, Shuang-Jiang,Wang, Xue-Yi,et al. Effects of cannabinoid CB1 receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice[J]. BEHAVIOURAL BRAIN RESEARCH,2011,217(1):111-116.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Lu-Lu]'s Articles
[Zhou, Shuang-Jiang]'s Articles
[Wang, Xue-Yi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Lu-Lu]‘s Articles
[Zhou, Shuang-Jiang]‘s Articles
[Wang, Xue-Yi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace