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学科主题: 临床医学
题名:
Optimal Dosage of Botulinum Toxin Type A for Treatment of Glabellar Frown Lines: Efficacy and Safety in a Clinical Trial
作者: Feng, Zheng1; Sun, Qiuning2; He, Li3; Wu, Yan4; Xie, Hongfu5; Zhao, Guang6; Xu, Jinhua7; Yao, Chen8; Li, Hengjin1
刊名: DERMATOLOGIC SURGERY
发表日期: 2015
DOI: 10.1097/DSS.0000000000000265
卷: suppl.S, 期:1, 页:S56-S63
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology ; Surgery
研究领域[WOS]: Dermatology ; Surgery
关键词[WOS]: DOUBLE-BLIND ; INJECTION ; EXOTOXIN ; RHYTIDS
英文摘要:

BACKGROUND Various preparations of botulinum toxin type A (BTX-A) are used to reduces glabellar (frown) lines. However, dose-related safety and efficacy of intramuscular injections of a widely used, locally produced BTX-A in China has not been established.

OBJECTIVE Assessment of dose-dependent safety and efficacy of Chinese botulinum toxin type A (Hengli BTX-A [HBTX-A]) intramuscular injections on glabellar lines.

METHODS Four hundred eighty-eight BTX-A-naive participants were included in the double-blind trial and randomly divided into placebo (n = 122), low-dose (n = 183), and high-dose (n = 183) treatment groups for injection with saline solution, 10 units and 20 units of HBTX-A, respectively, at 4 sites in the corrugator muscle and 1 site in the procerus muscle. Outcomes were recorded before treatment and after 7, 30, 60, and 120 days, including glabellar line severity at maximum contraction and relaxation.

RESULTS Significantly greater improvement was observed in both HBTX-A groups in comparison with the placebo group (p <.05). Better efficacy was obtained in the high-dose treatment group. More participants developed adverse events after treatment with HBTX-A doses, than with the placebo (p <.05).

CONCLUSION Twenty-unit HBTX-A provided optimal improvement in glabellar lines, and its use might minimize injection frequency while maintaining acceptable safety.

语种: 英语
WOS记录号: WOS:000354110400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51554
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.PLA, Gen Hosp, Dept Dermatol, Beijing 100853, Peoples R China
2.PUMCH, Dept Dermatol, Beijing, Peoples R China
3.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming, Peoples R China
4.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China
5.Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China
6.PLA, Air Force Gen Hosp, Dept Dermatol, Beijing 100853, Peoples R China
7.Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China
8.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China

Recommended Citation:
Feng, Zheng,Sun, Qiuning,He, Li,et al. Optimal Dosage of Botulinum Toxin Type A for Treatment of Glabellar Frown Lines: Efficacy and Safety in a Clinical Trial[J]. DERMATOLOGIC SURGERY,2015,suppl.S(1):S56-S63.
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