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学科主题: 临床医学
题名:
General adverse response to cyclophosphamide in Chinese patients with systemic autoimmune diseases in recent decade - a single-center retrospective study
作者: Li, Juan1,2; Dai, Guowei3; Zhang, Zhuoli1
关键词: Adverse drug reaction ; Autoimmune diseases ; Cyclophosphamide
刊名: CLINICAL RHEUMATOLOGY
发表日期: 2015-02-01
DOI: 10.1007/s10067-014-2748-2
卷: 34, 期:2, 页:273-278
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: LUPUS-ERYTHEMATOSUS ; HEMORRHAGIC CYSTITIS ; OVARIAN FAILURE ; IN-VIVO ; THERAPY ; METABOLITES ; TOXICITY ; ACROLEIN ; WOMEN
英文摘要:

This study was conducted to investigate the adverse reaction to cyclophosphamide (CYC) in Chinese patients with systemic autoimmune diseases. Patients with systemic autoimmune diseases who were exposed to CYC and followed up regularly for at least 2 years in Rheumatology Department during June 2003 to June 2013 were enrolled into this study. Participants were divided into per oral (PO) group and intravenous (IV) group. The adverse effects to CYC were recorded and analyzed. A total of 419 patients were enrolled in this study. The occurrence rates of gastrointestinal discomfort, alopecia, myelosuppression, secondary infection, abnormal liver function, dizziness/headache, menstrual disturbance and reversal to normal menstruation after discontinuation of CYC were 21.5 %, 12.4 %, 7.4 %, 3.6 %, 3.1 %, 3.1 %, 30.3 % and 31.0 %, respectively. None of the patients had hemorrhagic cystitis. The significant risk factors for gastrointestinal discomfort were female, exposure to CYC for a long time and intravenous route. Risk factors for mylosuppression were female and combination with other immunosuppressants. Risk factors were female gender for alopecia and older age for menstrual disturbance. Female patients were much more likely to have gastrointestinal discomfort, mylosuppression and alopecia when CYC was administrated intravenously. Risk factors were older age for menstrual disturbance and the combination with other immunosuppressants for myelosuppression. Hemorrhagic cystitis did not appear in our series for the possible reason of prophylactic hydration before intravenous injection and maybe racial difference.

语种: 英语
WOS记录号: WOS:000348803000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51555
Appears in Collections:北京大学第一临床医学院_风湿免疫科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Rheumatol, Beijing 100034, Peoples R China
2.Gen Hosp TISCO, Renal Dept, Taiyuan, Peoples R China
3.Yellow River Hosp, Tradit Chinese Med Dept, Sanmenxia, Peoples R China

Recommended Citation:
Li, Juan,Dai, Guowei,Zhang, Zhuoli. General adverse response to cyclophosphamide in Chinese patients with systemic autoimmune diseases in recent decade - a single-center retrospective study[J]. CLINICAL RHEUMATOLOGY,2015,34(2):273-278.
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