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Estrogen receptor-alpha gene polymorphisms in patients with periodontitis
Zhang, L1; Meng, HX1; Zhao, HS1; Li, QY1; Xu, L1; Chen, ZB1; Shi, D1; Feng, XH1
关键词Estrogen Receptor-alpha Gene Periodontitis Polymorphism Susceptibility
刊名JOURNAL OF PERIODONTAL RESEARCH
2004-10-01
DOI10.1111/j.1600-0765.2004.00736.x
39期:5页:362-366
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]BONE-MINERAL DENSITY ; FRAGMENT-LENGTH-POLYMORPHISM ; BREAST-CANCER ; POSTMENOPAUSAL WOMEN ; ASSOCIATION ; GENOTYPES ; DISEASES ; EXPRESSION ; CELLS
英文摘要

Background: Recent studies have shown that estrogen receptor-alpha (ER-alpha) gene polymorphisms are associated with alterations in bone mineral density and osteoporosis. It is unclear whether ER-alpha gene polymorphisms are associated with alveolar bone loss in patients with periodontitis.

Objective: The aim of this study was to investigate the relationship between ER-alpha gene polymorphisms and periodontitis.

Methods: Ninety patients with aggressive periodontitis, 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. All these subjects belonged to the Han Chinese race. DNA was extracted from peripheral blood of each subject. The ER-alpha gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with PvuII and XbaI restriction endonucleases.

Results: The detection frequency of XX genotype was significantly higher in the chronic periodontitis patients than in the healthy controls (11.8% vs. 4.4%, p < 0.05). The difference between the female chronic periodontitis patients and healthy controls (26.7% vs. 2.1%, p < 0.01) was statistically significant, but no difference was found between the male patients and controls (p > 0.05). The detection frequency of PvuII ER genotypes was not statistically different among the three groups (p > 0.05).

Conclusions: In female Han Chinese population, the XX genotype may be a risk indicator for chronic periodontitis.

语种英语
WOS记录号WOS:000223471100011
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51558
专题北京大学口腔医学院_牙周科
北京大学基础医学院
北京大学第三临床医学院_麻醉科
作者单位1.Peking Univ, Sch Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, L,Meng, HX,Zhao, HS,et al. Estrogen receptor-alpha gene polymorphisms in patients with periodontitis[J]. JOURNAL OF PERIODONTAL RESEARCH,2004,39(5):362-366.
APA Zhang, L.,Meng, HX.,Zhao, HS.,Li, QY.,Xu, L.,...&Feng, XH.(2004).Estrogen receptor-alpha gene polymorphisms in patients with periodontitis.JOURNAL OF PERIODONTAL RESEARCH,39(5),362-366.
MLA Zhang, L,et al."Estrogen receptor-alpha gene polymorphisms in patients with periodontitis".JOURNAL OF PERIODONTAL RESEARCH 39.5(2004):362-366.
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