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学科主题: 口腔医学
题名:
Estrogen receptor-alpha gene polymorphisms in patients with periodontitis
作者: Zhang, L1; Meng, HX1; Zhao, HS1; Li, QY1; Xu, L1; Chen, ZB1; Shi, D1; Feng, XH1
关键词: estrogen receptor-alpha gene ; periodontitis ; polymorphism ; susceptibility
刊名: JOURNAL OF PERIODONTAL RESEARCH
发表日期: 2004-10-01
DOI: 10.1111/j.1600-0765.2004.00736.x
卷: 39, 期:5, 页:362-366
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: BONE-MINERAL DENSITY ; FRAGMENT-LENGTH-POLYMORPHISM ; BREAST-CANCER ; POSTMENOPAUSAL WOMEN ; ASSOCIATION ; GENOTYPES ; DISEASES ; EXPRESSION ; CELLS
英文摘要:

Background: Recent studies have shown that estrogen receptor-alpha (ER-alpha) gene polymorphisms are associated with alterations in bone mineral density and osteoporosis. It is unclear whether ER-alpha gene polymorphisms are associated with alveolar bone loss in patients with periodontitis.

Objective: The aim of this study was to investigate the relationship between ER-alpha gene polymorphisms and periodontitis.

Methods: Ninety patients with aggressive periodontitis, 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. All these subjects belonged to the Han Chinese race. DNA was extracted from peripheral blood of each subject. The ER-alpha gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with PvuII and XbaI restriction endonucleases.

Results: The detection frequency of XX genotype was significantly higher in the chronic periodontitis patients than in the healthy controls (11.8% vs. 4.4%, p < 0.05). The difference between the female chronic periodontitis patients and healthy controls (26.7% vs. 2.1%, p < 0.01) was statistically significant, but no difference was found between the male patients and controls (p > 0.05). The detection frequency of PvuII ER genotypes was not statistically different among the three groups (p > 0.05).

Conclusions: In female Han Chinese population, the XX genotype may be a risk indicator for chronic periodontitis.

语种: 英语
WOS记录号: WOS:000223471100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51558
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, L,Meng, HX,Zhao, HS,et al. Estrogen receptor-alpha gene polymorphisms in patients with periodontitis[J]. JOURNAL OF PERIODONTAL RESEARCH,2004,39(5):362-366.
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