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Risk factors affecting nasal colonization of methicillin-resistant Staphylococcus aureus when admitted in intensive care unit
Li Qiang1; Zhuang Taifeng2; Lin Ying1; Xi Jingjing1; Yao Gaiqi1
关键词Methicillin-resistant Staphylococcus Aureus Polymerase Chain Reaction Intensive Care Unit Risk Factors
刊名CHINESE MEDICAL JOURNAL
2014-05-20
DOI10.3760/cma.j.issn.0366-6999.20140050
127期:10页:1804-1807
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]PREVALENCE ; INFECTION ; MRSA ; CARRIAGE ; WORKERS ; PCR
英文摘要

Background Colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a risk factor for subsequent invasive MRSA infection, particularly in patients admitted for critical care. The purpose of this study was to investigate the risk factors affecting nasal colonization of MRSA in patients admitted to intensive care units (ICU).

Methods Between August 1, 2011 and June 30, 2012, we screened for MRSA nasal colonization in 350 patients by Real-time PCR within 24 hours of admission by means of swab samples taken from the anterior nares. According to the results of PCR, the patients were divided into 2 groups: the positive group with nasal MRSA colonization and the negative group without nasal MRSA colonization. The 31 (8.86%) patients were MRSA positive. The risk factors evaluated included thirteen variables, which were analyzed by t test for continuous variables and X-2 test for discrete variables. The variables with significance (P <0.05) were analyzed with stepwise Logistic regression.

Results There were differences (P <0.05) in four variables between two groups. The duration of stay in hospital prior to ICU admission in the positive group was (35.7 +/- 16.1) days, vs. (4.5 +/- 3.1) days in the negative group. The average blood albumin level was (28.4 +/- 2.9) g/L in the positive group, vs. (30.5 +/- 4.3) g/L in the negative group. Of 31 patients in the positive group, seven had been treated with antibiotics longer than seven days vs. 34 of 319 patients in the negative group. In the positive group, four of 31 patients received treatment with more than two classes of antibiotics prior to admission in ICU, contrasted to 13 of 319 patients in the negative group. Furthermore, stepwise Logistic regression analysis for these four variables indicates that the duration of stay in hospital prior to ICU admission may be an independent risk factor.

Conclusions MRSA colonization in ICU admission may be related to many factors. The duration of stay in hospital prior to ICU admission is an independent risk factor.

语种英语
WOS记录号WOS:000336477100002
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51564
专题北京大学第三临床医学院_危重医学科
北京大学第一临床医学院_整形烧伤外科
作者单位1.Peking Univ, Hosp 3, Intens Care Unit, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Neonatol, Beijing 100026, Peoples R China
推荐引用方式
GB/T 7714
Li Qiang,Zhuang Taifeng,Lin Ying,et al. Risk factors affecting nasal colonization of methicillin-resistant Staphylococcus aureus when admitted in intensive care unit[J]. CHINESE MEDICAL JOURNAL,2014,127(10):1804-1807.
APA Li Qiang,Zhuang Taifeng,Lin Ying,Xi Jingjing,&Yao Gaiqi.(2014).Risk factors affecting nasal colonization of methicillin-resistant Staphylococcus aureus when admitted in intensive care unit.CHINESE MEDICAL JOURNAL,127(10),1804-1807.
MLA Li Qiang,et al."Risk factors affecting nasal colonization of methicillin-resistant Staphylococcus aureus when admitted in intensive care unit".CHINESE MEDICAL JOURNAL 127.10(2014):1804-1807.
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