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学科主题基础医学
Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1 alpha-Sirt3 Axis
Yu, Xiaoyan1,2; Zhang, Li1,2; Yang, Xiuying1,2; Huang, Huakang3; Huang, Zhonglin1,2; Shi, Lili4; Zhang, Hengai5; Du, Guanhua1,2
关键词Salvianolic Acid a Diabetic Neuropathy Amp-activated Protein Kinase
刊名MOLECULES
2012-09-01
DOI10.3390/molecules170911216
17期:9页:11216-11228
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]SKELETAL-MUSCLE ; OXIDATIVE STRESS ; AMPK ; KINASE ; NEURODEGENERATION ; PHOSPHORYLATION ; NEUROPATHIES ; PATHWAY ; CANCER
英文摘要

Salvianolic acid A (SalA) is one of the main efficacious, water-soluble constituents of Salvia miltiorrhiza Bunge. This study investigated the protective effects of SalA on peripheral nerve in diabetic rats. Administration of SalA (0.3, 1 and 3 mg/kg, ig) was started from the 5th week after strepotozotocin (STZ60 mg/kg) intraperitoneal injection and continued for 8 weeks. Paw withdrawal mechanical threshold (PWMT) and motor nerve conduction velocity (MNCV) were used to assess peripheral nerve function. The western blot methods were employed to test the expression levels of serine-threonine liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1 alpha), silent information regulator protein3 (sirtuin 3/Sirt3) and neuronal nitric oxide synthase (nNOS) in sciatic nerve. Results showed that SalA administration could increase PWMT and MNCV in diabetic rats; reduce the deterioration of sciatic nerve pathology; increase AMPK phosphorylation level, up-regulate PGC-1 alpha, Sirt3 and nNOS expression, but had no influence on LKB1. These results suggest that SalA has protective effects against diabetic neuropathy. The beneficial effects of SalA on peripheral nerve function in diabetic rats might be attributed to improvements in glucose metabolism through regulation of the AMPK-PGC1 alpha-Sirt3 axis.

语种英语
WOS记录号WOS:000309269700086
项目编号2009ZX09102-123 ; 2009ZX09302-003 ; 81102492 ; 2009DFA32010
资助机构National Science and Technology Major Project ; National Natural Science Foundation of China ; International Science &amp ; Technology Cooperation Projects
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51566
专题北京大学基础医学院_药理学系
作者单位1.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China
2.Peking Union Med Coll, Beijing 100050, Peoples R China
3.Peking Univ, HSC, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
4.Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China
5.Chinese Acad Sci, Inst Zool, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Yu, Xiaoyan,Zhang, Li,Yang, Xiuying,et al. Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1 alpha-Sirt3 Axis[J]. MOLECULES,2012,17(9):11216-11228.
APA Yu, Xiaoyan.,Zhang, Li.,Yang, Xiuying.,Huang, Huakang.,Huang, Zhonglin.,...&Du, Guanhua.(2012).Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1 alpha-Sirt3 Axis.MOLECULES,17(9),11216-11228.
MLA Yu, Xiaoyan,et al."Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1 alpha-Sirt3 Axis".MOLECULES 17.9(2012):11216-11228.
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