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学科主题: 基础医学
题名:
Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1 alpha-Sirt3 Axis
作者: Yu, Xiaoyan1,2; Zhang, Li1,2; Yang, Xiuying1,2; Huang, Huakang3; Huang, Zhonglin1,2; Shi, Lili4; Zhang, Hengai5; Du, Guanhua1,2
关键词: salvianolic acid A ; diabetic neuropathy ; AMP-activated protein kinase
刊名: MOLECULES
发表日期: 2012-09-01
DOI: 10.3390/molecules170911216
卷: 17, 期:9, 页:11216-11228
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: SKELETAL-MUSCLE ; OXIDATIVE STRESS ; AMPK ; KINASE ; NEURODEGENERATION ; PHOSPHORYLATION ; NEUROPATHIES ; PATHWAY ; CANCER
英文摘要:

Salvianolic acid A (SalA) is one of the main efficacious, water-soluble constituents of Salvia miltiorrhiza Bunge. This study investigated the protective effects of SalA on peripheral nerve in diabetic rats. Administration of SalA (0.3, 1 and 3 mg/kg, ig) was started from the 5th week after strepotozotocin (STZ60 mg/kg) intraperitoneal injection and continued for 8 weeks. Paw withdrawal mechanical threshold (PWMT) and motor nerve conduction velocity (MNCV) were used to assess peripheral nerve function. The western blot methods were employed to test the expression levels of serine-threonine liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1 alpha), silent information regulator protein3 (sirtuin 3/Sirt3) and neuronal nitric oxide synthase (nNOS) in sciatic nerve. Results showed that SalA administration could increase PWMT and MNCV in diabetic rats; reduce the deterioration of sciatic nerve pathology; increase AMPK phosphorylation level, up-regulate PGC-1 alpha, Sirt3 and nNOS expression, but had no influence on LKB1. These results suggest that SalA has protective effects against diabetic neuropathy. The beneficial effects of SalA on peripheral nerve function in diabetic rats might be attributed to improvements in glucose metabolism through regulation of the AMPK-PGC1 alpha-Sirt3 axis.

语种: 英语
所属项目编号: 2009ZX09102-123 ; 2009ZX09302-003 ; 81102492 ; 2009DFA32010
项目资助者: National Science and Technology Major Project ; National Natural Science Foundation of China ; International Science &amp ; Technology Cooperation Projects
WOS记录号: WOS:000309269700086
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51566
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China
2.Peking Union Med Coll, Beijing 100050, Peoples R China
3.Peking Univ, HSC, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
4.Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China
5.Chinese Acad Sci, Inst Zool, Beijing 100101, Peoples R China

Recommended Citation:
Yu, Xiaoyan,Zhang, Li,Yang, Xiuying,et al. Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1 alpha-Sirt3 Axis[J]. MOLECULES,2012,17(9):11216-11228.
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