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学科主题临床医学
Effects of physical exercise on health-related quality of life and blood lipids in perimenopausal women: a randomized placebo-controlled trial
Zhang, Jing1; Chen, Guiping1; Lu, Weiwei2; Yan, Xiaoyan3; Zhu, Sainan4; Dai, Yue2; Xi, Sisi1; Yao, Chen3,4; Bai, Wenpei1
关键词Perimenopausal Syndrome Symptoms Physical Exercise Therapy Blood Lipids
刊名MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
2014-12-01
DOI10.1097/gme.0000000000000264
21期:12页:1269-1276
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]HEART-RATE-VARIABILITY ; POSTMENOPAUSAL WOMEN ; MENOPAUSAL SYMPTOMS ; HOT FLASHES ; MUSCULOSKELETAL PAIN ; VASOMOTOR SYMPTOMS ; HORMONE-THERAPY ; MIDLIFE WOMEN ; BLACK COHOSH ; PREVALENCE
英文摘要

Objective: This study aims to evaluate the treatment effects of physical exercise on menopausal symptoms in middle-aged female medical staff experiencing perimenopausal syndrome.

Methods: A total of 157 female medical staff aged 40 to 55 years and with a Kupperman index score of 15 points or higher were randomized 1: 1 into an intervention group (n = 78) or a control group (n = 79). Women in the intervention group were asked to perform aerobic physical exercise (walking with strides) three times a week or more, whereas those in the control group continued as normal. Measurements were taken at baseline and on weeks 4, 8, and 12, with total Kupperman index score, scores on individual elements of the scale, weight, and waist circumference recorded. In addition, fasting blood glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were recorded at baseline and on week 12. The effects of physical exercise therapy on perimenopausal syndrome were evaluated by comparing changes in these parameters between the control group and the intervention group.

Results: Fifty-four and 57 women completed all three follow-ups in the intervention and control groups, respectively. On week 12, the mean (SD) change in total Kupperman index score (-9.23 [6.23]) from baseline to week 12; the mean (SD) changes in individual scores for paresthesia (-1.08 [1.51]), insomnia (-1.00 [1.46]), irritability (-1.00 [1.34]), joint or muscle pain (-0.75 [0.74]), fatigue (-0.56 [0.75]), headache (-0.54 [0.75]), formication (-0.38 [0.66]), and sexual life (-0.62 [1.71]); and the mean (SD) changes in total cholesterol (-0.76 [0.63] mmol/L) and triglycerides (-0.20 [0.50] mmol/L) were significantly higher in the intervention group than in the control group (P < 0.05). In the intervention group, total Kupperman index score, weight, body mass index, waist circumference, triglycerides, and total cholesterol were significantly lower on week 12 compared with baseline (P < 0.05).

Conclusions: Physical exercise can substantially reduce menopausal symptoms and improve blood lipid status and body weight.

语种英语
WOS记录号WOS:000345846600005
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51575
专题北京大学第一临床医学院_妇产科
北京大学第一临床医学院_工会
北京大学第一临床医学院_医学统计室
作者单位1.Peking Univ, Union Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Gynecol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Med Stat, Beijing 100871, Peoples R China
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GB/T 7714
Zhang, Jing,Chen, Guiping,Lu, Weiwei,et al. Effects of physical exercise on health-related quality of life and blood lipids in perimenopausal women: a randomized placebo-controlled trial[J]. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY,2014,21(12):1269-1276.
APA Zhang, Jing.,Chen, Guiping.,Lu, Weiwei.,Yan, Xiaoyan.,Zhu, Sainan.,...&Bai, Wenpei.(2014).Effects of physical exercise on health-related quality of life and blood lipids in perimenopausal women: a randomized placebo-controlled trial.MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY,21(12),1269-1276.
MLA Zhang, Jing,et al."Effects of physical exercise on health-related quality of life and blood lipids in perimenopausal women: a randomized placebo-controlled trial".MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 21.12(2014):1269-1276.
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