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IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科  > 期刊论文
学科主题: 临床医学
题名:
Hypertrophic cardiomyopathy: Cardiac structural and microvascular abnormalities as evaluated with multi-parametric MRI
作者: Zhang, Yu-Dong1; Li, Meijiao2; Qi, Liang1; Wu, Chen-Jiang1; Wang, Xiaoying2
关键词: Hypertrophic cardiomyopathy ; Cardiac MRI ; Myocardial perfusion ; Structural abnormality ; Microvascular dysfunction
刊名: EUROPEAN JOURNAL OF RADIOLOGY
发表日期: 2015-08-01
DOI: 10.1016/j.ejrad.2015.04.028
卷: 84, 期:8, 页:1480-1486
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: CARDIOVASCULAR MAGNETIC-RESONANCE ; LATE GADOLINIUM ENHANCEMENT ; ABSOLUTE MYOCARDIAL-PERFUSION ; EXTRACELLULAR VOLUME FRACTION ; DELAYED ENHANCEMENT ; PROGNOSTIC-SIGNIFICANCE ; QUANTITATIVE-ANALYSIS ; BLOOD-FLOW ; QUANTIFICATION ; FIBROSIS
英文摘要:

Purpose: To determine the relationship between myocardial structural and microvascular abnormality in hypertrophic cardiomyopathy (HCM) by multi-parametric cardiac MRI.

Materials and methods: Twenty-four HCM and eighteen controls were retrospectively included. Left ventricle mass (LVM), LV end-systolic and end-diastolic volume (LVESV, LVEDV), LV ejection fraction (LVEF), and 16-segment wall thickness at ES and ED (SESWT, SEDWT) were assessed with a 2D cine-MRI. Myocardial perfusion (reflected by K-trans), interstitial volume (V-e) and mean transmit time (MTT) were evaluated with a model-dependent dynamic contrast-enhanced MRI. Myocardial fibrosis was assessed with late gadolinium enhancement (LGE) imaging.

Results: K-trans was significantly decreased in LGE-present (0.74 perpendicular to 0.15 mL/g/min) against LGE-absent( 0.55 +/- 0.14 mL/g/min, p = 0.030) and normal group (0.81 +/- 0.32 mL/g/min, p < 0.001), but was unchanged in LGE-absent against normal group (p > 0.05). Veand MTT were significantly increased in LGE-present( V-e: 26.7 +/- 15.7%; MTT: 28.6 +/- 21.3 s) against LGE-absent (37.6 +/- 18.3%; 49.8 +/- 30.5 s) and normal group( 19.7 +/- 6.9%; 15.1 +/- 3.9 s; all p < 0.001), and were significantly increased in LGE- absent against normal group (p < 0.001). LGE significantly correlated to K-trans, V-e, MTT, and SESWT (rho = 0.232, -0.247, -0.443, and -0.207, respectively). K-trans negatively correlated to SEDWT and SESWT (rho = -0.224 and -0.231). Veand MTT positively correlated to SEDWT (V-e: rho = 0.223; MTT: rho = 0.239) and SESWT (Ve: rho = 0.248; MTT: rho = 0.254).

Conclusions: Consistent relationship was determined between myocardial structural abnormality and microvascular dysfunction in HCM. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000357474200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51576
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
2.Nanjing Med Univ, Affiliated Hosp 1, Dept Radiol, Nanjing, Peoples R China

Recommended Citation:
Zhang, Yu-Dong,Li, Meijiao,Qi, Liang,et al. Hypertrophic cardiomyopathy: Cardiac structural and microvascular abnormalities as evaluated with multi-parametric MRI[J]. EUROPEAN JOURNAL OF RADIOLOGY,2015,84(8):1480-1486.
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