IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3
Lu, Yanxin1,2; Yue, Xupeng2; Cui, Yuanyuan1; Zhang, Jufeng2; Wang, KeWei1,2,3
关键词miR-124 STAT3 Hepatocellular carcinoma Proliferation Apoptosis
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2013-11-29
DOI10.1016/j.bbrc.2013.10.157
441期:4页:873-879
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Science Foundation of China ; Ministry of Science Technology of China ; National Science Foundation of China ; Ministry of Science Technology of China
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]MIR-124 ; PROLIFERATION ; ACTIVATION ; ONCOGENE ; PATHWAYS ; CANCER ; CELLS
英文摘要

The aberrant expression of microRNAs is associated with development and progression of cancers. Downregulation of miR-124 has been demonstrated in the hepatocellular carcinoma (HCC), but the underlying mechanism by which miR-124 suppresses tumorigenesis in HCC remains elusive. In this study, we found that miR-124 suppresses the tumor growth of HCC through targeting the signal transducers and activators of transcription 3 (STAT3). Overexpression of miR-124 suppressed proliferation and induced apoptosis in HepG-2 cells. Luciferase assay confirmed that miR-124 binding to the 3′-UTR region of STAT3 inhibited the expression of STAT3 and phosphorylated STAT3 proteins in HepG-2 cells. Knockdown of STAT3 by siRNA in HepG-2 cells mimicked the effect induced by miR-124. Overexpression of STAT3 in miR-124-transfected HepG-2 cells effectively rescued the inhibition of cell proliferation caused by miR-124. Furthermore, miR-124 suppressed xenograft tumor growth in nude mice implanted with HepG-2 cells by reducing STAT3 expression. Taken together, our findings show that miR-124 functions as tumor suppressor in HCC by targeting STAT3, and miR-124 may therefore serve as a biomarker for diagnosis and therapeutics in HCC. (C) 2013 Published by Elsevier Inc.

语种英语
所属项目编号30970919 ; 2009ZX09301-010
资助者National Science Foundation of China ; Ministry of Science Technology of China ; National Science Foundation of China ; Ministry of Science Technology of China
WOS记录号WOS:000328434800031
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51583
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Dept Neurobiol, Beijing 100191, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Lu, Yanxin,Yue, Xupeng,Cui, Yuanyuan,et al. MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,441(4):873-879.
APA Lu, Yanxin,Yue, Xupeng,Cui, Yuanyuan,Zhang, Jufeng,&Wang, KeWei.(2013).MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,441(4),873-879.
MLA Lu, Yanxin,et al."MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441.4(2013):873-879.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
MicroRNA-124 suppres(1890KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lu, Yanxin]的文章
[Yue, Xupeng]的文章
[Cui, Yuanyuan]的文章
百度学术
百度学术中相似的文章
[Lu, Yanxin]的文章
[Yue, Xupeng]的文章
[Cui, Yuanyuan]的文章
必应学术
必应学术中相似的文章
[Lu, Yanxin]的文章
[Yue, Xupeng]的文章
[Cui, Yuanyuan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。