学科主题基础医学
B-MYB delays cell aging by repressing p16 (INK4 alpha) transcription
Huang, Yu1,2; Wu, Junfeng1,3; Li, Renzhong1,3; Wang, Peichang1,3; Han, Limin1,3; Zhang, Zongyu1,3; Tong, Tanjun1,3
关键词P16(Ink4 Alpha) B-myb Senescence Cell Aging Transcriptional Regulation
刊名CELLULAR AND MOLECULAR LIFE SCIENCES
2011-03-01
DOI10.1007/s00018-010-0501-9
68期:5页:893-901
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]HUMAN-DIPLOID FIBROBLASTS ; P16(INK4A) EXPRESSION ; INHIBITOR P16(INK4A) ; GROWTH-FACTOR ; C-MYB ; SENESCENCE ; PROTEINS ; DNA ; PROLIFERATION ; OVEREXPRESSION
英文摘要

p16 (INK4 alpha) , an inhibitor of cyclin-dependent kinase 4 and 6, has been proposed to play an important role in cellular aging and in premature senescence. The expression of the p16 (INK4 alpha) is primarily under transcriptional control. Our previous data showed that a negative regulation element lies in its promoter. In that element, a MYB-binding site (MBS) was uncovered by transcription analysis. Here, we report that MBS is a negative regulation element and B-MYB binds to this site in vivo. In human embryonic lung fibroblast cells, B-MYB downregulated p16 (INK4 alpha) expression, whereas knocking down of B-MYB upregulated it. Evidence also showed that overexpression of B-MYB in cells could increase the number of utmost passage and decrease G1 block, whereas knocking down of B-MYB could impair their replicative ability. This study provides evidence of the capacity of B-MYB not only to regulate p16 (INK4 alpha) expression but also the phenotypic consequence on cellular senescence.

语种英语
WOS记录号WOS:000287243400011
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51584
专题北京大学基础医学院_北京大学衰老研究中心
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Res Ctr Aging, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Genet, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
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Huang, Yu,Wu, Junfeng,Li, Renzhong,et al. B-MYB delays cell aging by repressing p16 (INK4 alpha) transcription[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2011,68(5):893-901.
APA Huang, Yu.,Wu, Junfeng.,Li, Renzhong.,Wang, Peichang.,Han, Limin.,...&Tong, Tanjun.(2011).B-MYB delays cell aging by repressing p16 (INK4 alpha) transcription.CELLULAR AND MOLECULAR LIFE SCIENCES,68(5),893-901.
MLA Huang, Yu,et al."B-MYB delays cell aging by repressing p16 (INK4 alpha) transcription".CELLULAR AND MOLECULAR LIFE SCIENCES 68.5(2011):893-901.
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