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学科主题: 临床医学
题名:
Prevalence and genetic diversity of pneumococcal serogroup 6 in Australia
作者: Zhuo, F.1,2; Xiao, M.3; Kong, F.1; Oftadeh, S.1; Zhou, F.1; Zhang, J.2; Gilbert, G. L.1
关键词: Antibiotic susceptibility ; diversity ; genotypes ; serotypes 6C and 6D ; Streptococcus pneumoniae
刊名: CLINICAL MICROBIOLOGY AND INFECTION
发表日期: 2011-08-01
DOI: 10.1111/j.1469-0691.2010.03404.x
卷: 17, 期:8, 页:1246-1253
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: STREPTOCOCCUS-PNEUMONIAE SEROTYPE ; CONJUGATE VACCINE ; UNITED-STATES ; INVASIVE DISEASE ; CHILDREN ; PCR ; ERA ; IDENTIFICATION ; EMERGENCE ; 19A
英文摘要:

The prevalence of the newly discovered pneumococcal serotype 6C has increased in some countries since the introduction of seven-valent conjugate pneumococcal vaccine (PCV7). The distribution of invasive serogroup 6 serotypes, in Australia, including 6C and 6D, has not been reported previously. During the period 1999 to 2008, 6097 isolates were referred to the New South Wales Pneumococcal Reference Laboratory for serotyping. Of these, 847 were identified by Quellung reaction as belonging to serogroup 6 and 702 were available for further study. Serotypes were determined by serotype-specific PCR as follows: 6A, 197 (28.1%); 6B, 452 (64.4%); 6C, 52 (7.4%) and one 6D. The average numbers of invasive serogroup 6 isolates, per annum, fell from 62.2 before (2000-2005) to 49.7 after (2006-2008) the introduction of PCV7. The proportions of invasive 6B fell (from 72.4% to 47.3%, p 0.03), those of 6C rose (from 3.3% to 17%, p 0.02) significantly and those of 6A remained fairly constant (24.3% vs 27%, p 0.69) between the two periods. All 6C and 6D and selected 6A and 6B isolates were further characterized by multilocus sequence typing and sequence analysis of cps genes cpsA-cpsB (wzg-wzh) and wchA-wciN(beta)-wciO, wciP. Results showed considerable diversity within serotype 6C, apparently as a result of both mutation and recombination. Sequence typing indicates that, in Australia, 6C has been largely derived from 6A. The genetic diversity and rapid increase in incidence of serotype 6C causing invasive pneumococcal disease has potential implications for vaccine efficacy.

语种: 英语
所属项目编号: R01 AI 52337 ; 358351
项目资助者: Chinese Government ; National Institutes of Health DMID ; National Health and Medical Research Council (NHMRC) ; Wyeth Australia (Pty Ltd) ; Glaxo-SmithKline
WOS记录号: WOS:000293030500027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51587
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Peking Univ, Life Sci Coll, Beijing 100871, Peoples R China
2.Westmead Hosp, CIDM, ICPMR, Westmead, NSW 2145, Australia
3.Peking Univ Peoples Hosp, Dept Dermatol, Beijing, Peoples R China

Recommended Citation:
Zhuo, F.,Xiao, M.,Kong, F.,et al. Prevalence and genetic diversity of pneumococcal serogroup 6 in Australia[J]. CLINICAL MICROBIOLOGY AND INFECTION,2011,17(8):1246-1253.
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