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学科主题: 口腔医学
题名:
Improvement of fibroblast adherence to titanium surface by calcium phosphate coating formed with IBAD
作者: Zhao, BH1; Lee, IS1; Bai, W1; Cui, FZ1; Feng, HL1
关键词: TCP/HA ; IBAD ; cell attachment ; ECM ; focal adhesion plaque
刊名: SURFACE & COATINGS TECHNOLOGY
发表日期: 2005-04-01
DOI: 10.1016/j.surfcoat.2004.07.041
卷: 193, 期:1-3, 页:366-371
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Coatings & Films ; Physics, Applied
研究领域[WOS]: Materials Science ; Physics
关键词[WOS]: HYDROXYAPATITE COATINGS ; DENTAL IMPLANTS ; IN-VITRO ; HYDROXYLAPATITE ; COMPLICATIONS ; ATTACHMENT ; PROSTHESES ; ALLOY ; CELLS
英文摘要:

Coatings of hydroxyapatite (HA) and duplex phases of tricalcium phosphate/hydroxyapatite (TCP/HA) on titanium (Ti) were formed by ion beam-assisted deposition (IBAD). Human gingival fibroblasts (HGFs) attachment, spreading, extracellular matrix (ECM) production, and focal adhesion plaque formation were investigated on commercially pure titanium (cpTi), HA-coated cpTi, and porous TCP/HA-coated cpTi. After standard cell culture of HGFs on these substrates, attached cell number, cell spreading area, immunostained ECM including fibronectin (FN) and type I collage, and vinculin (presenting the formation of focal adhesion plaque) were quantified by morphometric analysis using an immunofluorescence microscope. TCP/HA and HA coatings exhibited that attached cell number and cell spreading area were higher than that of cpTi, and focal adhesion plaque formed earlier than that of uncoated substrate. The attached cell number and type I collagen formation on TCP/HA were more than that on HA. These results showed that significant improvement of soft tissue adherence to Ti surface was obtained by the porous TCP/HA coating. This indicated that this surface modification method may enhance the biological seal at the cervical level of the Ti dental implants. (c) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000227482300069
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51588
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
2.Yonsei Univ, Atom Scale Surface Sci Res Ctr, Seoul 120749, South Korea
3.Tsing Hua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China

Recommended Citation:
Zhao, BH,Lee, IS,Bai, W,et al. Improvement of fibroblast adherence to titanium surface by calcium phosphate coating formed with IBAD[J]. SURFACE & COATINGS TECHNOLOGY,2005,193(1-3):366-371.
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