北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 化学生物学系  > 期刊论文
学科主题: 药学
题名:
Studies on Synthesis and Bioactivity of N-8-Deaza-N-5-tetrahydrofolate Analogues
作者: Yan Rufeng; Tian Chao; Guo Ying; Zhang Zhili; Wang Xiaowei; Liu Junyi
关键词: N-8-deaza-N-5-substitutedtetrahydrofolate analogue ; dihydrofolate reductase ; anticancer activity
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2010-11-01
卷: 30, 期:11, 页:1721-1725
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ANTIFOLATE
英文摘要:

The backbone of folate analogue was obtained by linking diethyl-N-(p-aminobenzoyl)L-glutamate and 2-amino-4-hydroxy-6-(hydroxymethyl)pyrido[3,2-d]pyrimidine Three new 8-deazatetrahydrofolate analogues were synthesized after reducing the pyrimidine and linking different substituents on N-5 position The compounds were characterized by H-1 NMR and MS techniques The inhibitory activities of the compounds against human dihydrofolate reductase were determined The results showed that the bioactivities of the compounds were related with different substituents on N-5 position

语种: 中文
WOS记录号: WOS:000284983200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51595
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Yan Rufeng,Tian Chao,Guo Ying,et al. Studies on Synthesis and Bioactivity of N-8-Deaza-N-5-tetrahydrofolate Analogues[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2010,30(11):1721-1725.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yan Rufeng]'s Articles
[Tian Chao]'s Articles
[Guo Ying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yan Rufeng]‘s Articles
[Tian Chao]‘s Articles
[Guo Ying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace