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Studies on Synthesis and Bioactivity of N-8-Deaza-N-5-tetrahydrofolate Analogues
Yan Rufeng; Tian Chao; Guo Ying; Zhang Zhili; Wang Xiaowei; Liu Junyi
关键词N-8-deaza-n-5-substitutedtetrahydrofolate Analogue Dihydrofolate Reductase Anticancer Activity
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
2010-11-01
30期:11页:1721-1725
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]ANTIFOLATE
英文摘要

The backbone of folate analogue was obtained by linking diethyl-N-(p-aminobenzoyl)L-glutamate and 2-amino-4-hydroxy-6-(hydroxymethyl)pyrido[3,2-d]pyrimidine Three new 8-deazatetrahydrofolate analogues were synthesized after reducing the pyrimidine and linking different substituents on N-5 position The compounds were characterized by H-1 NMR and MS techniques The inhibitory activities of the compounds against human dihydrofolate reductase were determined The results showed that the bioactivities of the compounds were related with different substituents on N-5 position

语种中文
WOS记录号WOS:000284983200016
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51595
专题北京大学药学院_化学生物学系
北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yan Rufeng,Tian Chao,Guo Ying,et al. Studies on Synthesis and Bioactivity of N-8-Deaza-N-5-tetrahydrofolate Analogues[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2010,30(11):1721-1725.
APA Yan Rufeng,Tian Chao,Guo Ying,Zhang Zhili,Wang Xiaowei,&Liu Junyi.(2010).Studies on Synthesis and Bioactivity of N-8-Deaza-N-5-tetrahydrofolate Analogues.CHINESE JOURNAL OF ORGANIC CHEMISTRY,30(11),1721-1725.
MLA Yan Rufeng,et al."Studies on Synthesis and Bioactivity of N-8-Deaza-N-5-tetrahydrofolate Analogues".CHINESE JOURNAL OF ORGANIC CHEMISTRY 30.11(2010):1721-1725.
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