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Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study
An, Li1,2; Cao, Qing-Jiu1,2; Sui, Man-Qiu1,2; Sun, Li1,2; Zou, Qi-Hong3,4; Zang, Yu-Feng5,6,7,8; Wang, Yu-Feng1,2
关键词Resting State Functional Magnetic Resonance Imaging Regional Homogeneity Amplitude Of Low-frequency Fluctuation Attention-deficit/hyperactivity Disorder
刊名NEUROSCIENCE BULLETIN
2013-10-01
DOI10.1007/s12264-013-1353-8
29期:5页:603-613
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; LOW-FREQUENCY FLUCTUATION ; TEMPORAL-LOBE EPILEPSY ; MONKEY VISUAL-CORTEX ; FUNCTIONAL MRI ; REGIONAL HOMOGENEITY ; ALPHA-RHYTHM ; BLOOD-FLOW ; ADHD ; CONNECTIVITY
英文摘要

Regional homogeneity (ReHo) and the amplitude of low-frequency fluctuation (ALFF) are two approaches to depicting different regional characteristics of resting-state functional magnetic resonance imaging (RS-fMRI) data. Whether they can complementarily reveal brain regional functional abnormalities in attention-deficit/hyperactivity disorder (ADHD) remains unknown. In this study, we applied ReHo and ALFF to 23 medication-na < ve boys diagnosed with ADHD and 25 age-matched healthy male controls using whole-brain voxel-wise analysis. Correlation analyses were conducted in the ADHD group to investigate the relationship between the regional spontaneous brain activity measured by the two approaches and the clinical symptoms of ADHD. We found that the ReHo method showed widely-distributed differences between the two groups in the fronto-cingulo-occipito-cerebellar circuitry, while the ALFF method showed a difference only in the right occipital area. When a larger smoothing kernel and a more lenient threshold were used for ALFF, more overlapped regions were found between ALFF and ReHo, and ALFF even found some new regions with group differences. The ADHD symptom scores were correlated with the ReHo values in the right cerebellum, dorsal anterior cingulate cortex and left lingual gyrus in the ADHD group, while no correlation was detected between ALFF and ADHD symptoms. In conclusion, ReHo may be more sensitive to regional abnormalities, at least in boys with ADHD, than ALFF. And ALFF may be complementary to ReHo in measuring local spontaneous activity. Combination of the two may yield a more comprehensive pathophy-siological framework for ADHD.

语种英语
WOS记录号WOS:000324644400010
项目编号200802073 ; 2007BAI17B03 ; 30970802 ; 81000593 ; 81020108022 ; 81271652
资助机构Commonwealth Sciences Foundation, Ministry of Health, China ; National Basic Research Development Program, Ministry of Science and Technology, China ; National Natural Sciences Foundation of China ; State Key Laboratory of Cognitive Neuroscience and Learning
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51596
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, MRI Res Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Beijing Key Lab Med Phys & Engn, Beijing 100871, Peoples R China
5.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou 310015, Zhejiang, Peoples R China
6.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou 310015, Zhejiang, Peoples R China
7.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou 310015, Zhejiang, Peoples R China
8.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
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GB/T 7714
An, Li,Cao, Qing-Jiu,Sui, Man-Qiu,et al. Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study[J]. NEUROSCIENCE BULLETIN,2013,29(5):603-613.
APA An, Li.,Cao, Qing-Jiu.,Sui, Man-Qiu.,Sun, Li.,Zou, Qi-Hong.,...&Wang, Yu-Feng.(2013).Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study.NEUROSCIENCE BULLETIN,29(5),603-613.
MLA An, Li,et al."Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study".NEUROSCIENCE BULLETIN 29.5(2013):603-613.
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