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学科主题: 精神卫生
题名:
Altered volume and lateralization of language-related regions in first-episode schizophrenia
作者: Sheng, Jianhua1; Zhu, Yikang1; Lu, Zheng1,2; Liu, Na1; Huang, Nan1; Zhang, Zhongwei3; Tan, Ling3; Li, Chunbo1; Yu, Xin4,5
关键词: First-episode schizophrenia ; Gray matter change ; Cerebral asymmetry ; Neuropathology
刊名: SCHIZOPHRENIA RESEARCH
发表日期: 2013-08-01
DOI: 10.1016/j.schres.2013.05.021
卷: 148, 期:1-3, 页:168-174
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: VOXEL-BASED MORPHOMETRY ; EARLY-ONSET SCHIZOPHRENIA ; GRAY-MATTER VOLUME ; STATE FUNCTIONAL CONNECTIVITY ; ANOMALOUS CEREBRAL ASYMMETRY ; HOMO-SAPIENS PAYS ; PLANUM TEMPORALE ; LIKELIHOOD ESTIMATION ; FEMALE-PATIENTS ; DSM-IV
英文摘要:

Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-episode schizophrenia (FESZ), and their correlations with clinical measures. Magnetic resonance imaging scans were obtained froma total of 89 participants. Thirty-three FESZ patients and 41 matched healthy controls were included in the analysis. Compared to healthy controls, the FESZ patients showed decreased gray matter volume(GMV) in the frontal cortex, anterior cingulate cortex, temporal cortex, parahippocampal, fusiform, insula, and lingual; and increased GMV in cerebellum. Both male and female patients displayed an increased rightward lateralization in frontal and temporal cortex, which was significantly correlated with the severity of symptoms and social functioning. These findings may provide the neurological substrate for the etiology and clinical manifestations of the illness. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2007BAI17B04
项目资助者: Ministry of Science &amp ; Technology of China
WOS记录号: WOS:000323936600028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51603
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China
4.Tongji Univ, Shanghai Tongji Hosp, Dept Psychiat, Sch Med, Shanghai 200065, Peoples R China
5.Shanghai Jiao Tong Univ, Shanghai Rui Jin Hosp, Dept Radiol, Shanghai 200025, Peoples R China

Recommended Citation:
Sheng, Jianhua,Zhu, Yikang,Lu, Zheng,et al. Altered volume and lateralization of language-related regions in first-episode schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2013,148(1-3):168-174.
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