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Altered volume and lateralization of language-related regions in first-episode schizophrenia
Sheng, Jianhua1; Zhu, Yikang1; Lu, Zheng1,2; Liu, Na1; Huang, Nan1; Zhang, Zhongwei3; Tan, Ling3; Li, Chunbo1; Yu, Xin4,5
关键词First-episode Schizophrenia Gray Matter Change Cerebral Asymmetry Neuropathology
刊名SCHIZOPHRENIA RESEARCH
2013-08-01
DOI10.1016/j.schres.2013.05.021
148期:1-3页:168-174
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
资助者Ministry of Science &amp ; Technology of China ; Ministry of Science &amp ; Technology of China
研究领域[WOS]Psychiatry
关键词[WOS]VOXEL-BASED MORPHOMETRY ; EARLY-ONSET SCHIZOPHRENIA ; GRAY-MATTER VOLUME ; STATE FUNCTIONAL CONNECTIVITY ; ANOMALOUS CEREBRAL ASYMMETRY ; HOMO-SAPIENS PAYS ; PLANUM TEMPORALE ; LIKELIHOOD ESTIMATION ; FEMALE-PATIENTS ; DSM-IV
英文摘要

Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-episode schizophrenia (FESZ), and their correlations with clinical measures. Magnetic resonance imaging scans were obtained froma total of 89 participants. Thirty-three FESZ patients and 41 matched healthy controls were included in the analysis. Compared to healthy controls, the FESZ patients showed decreased gray matter volume(GMV) in the frontal cortex, anterior cingulate cortex, temporal cortex, parahippocampal, fusiform, insula, and lingual; and increased GMV in cerebellum. Both male and female patients displayed an increased rightward lateralization in frontal and temporal cortex, which was significantly correlated with the severity of symptoms and social functioning. These findings may provide the neurological substrate for the etiology and clinical manifestations of the illness. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2007BAI17B04
资助者Ministry of Science &amp ; Technology of China ; Ministry of Science &amp ; Technology of China
WOS记录号WOS:000323936600028
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51603
Collection北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China
4.Tongji Univ, Shanghai Tongji Hosp, Dept Psychiat, Sch Med, Shanghai 200065, Peoples R China
5.Shanghai Jiao Tong Univ, Shanghai Rui Jin Hosp, Dept Radiol, Shanghai 200025, Peoples R China
Recommended Citation
GB/T 7714
Sheng, Jianhua,Zhu, Yikang,Lu, Zheng,et al. Altered volume and lateralization of language-related regions in first-episode schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2013,148(1-3):168-174.
APA Sheng, Jianhua.,Zhu, Yikang.,Lu, Zheng.,Liu, Na.,Huang, Nan.,...&Yu, Xin.(2013).Altered volume and lateralization of language-related regions in first-episode schizophrenia.SCHIZOPHRENIA RESEARCH,148(1-3),168-174.
MLA Sheng, Jianhua,et al."Altered volume and lateralization of language-related regions in first-episode schizophrenia".SCHIZOPHRENIA RESEARCH 148.1-3(2013):168-174.
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