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Virological response to antiviral therapy at week 12 indicates a great reduction of intrahepatic hepatitis B virus DNA and cccDNA in HBeAg-positive chronic hepatitis B patients
Lu, H. Y.1; Zhuang, L. W.2; Yu, Y. Y.1; Si, C. W.1
关键词Covalently Closed Circular Dna Hepatitis b Virus Interferon-alpha 2b Lamivudine Virological Response
刊名JOURNAL OF VIRAL HEPATITIS
2010-03-01
DOI10.1111/j.1365-2893.2010.01272.x
suppl.1页:59-65
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
资助者Beijing Municipal Science and Technology Commission ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Beijing Municipal Science and Technology Commission ; Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]CLOSED CIRCULAR DNA ; ADEFOVIR DIPIVOXIL ; PEGINTERFERON ALPHA-2A ; LAMIVUDINE THERAPY ; ENTECAVIR ; MANAGEMENT ; COMBINATION ; PERSISTENCE ; WORKSHOP ; ROADMAP
英文摘要

Early virological response is considered to be a predictor for the outcome of anti-hepatitis B virus (HBV) therapy. To analyze its correlation to intrahepatic HBV DNA and covalently closed circular DNA (ccc)DNA, 71 hepatitis B virus e antigen (HBeAg)-positive chronic hepatitis B patients were recruited: 34 patients were treated with lamivudine; 13 with interferon-alpha 2b; and 24 with sequential therapy of lamivudine-interferon-alpha 2b for 48 weeks. Intrahepatic HBV DNA and cccDNA load were measured at the baseline and at Week 48. Fifty-seven patients had virological response at Week 12. Median decreases of serum HBV DNA in patients with or without virological response at Week 12 were 4.0 log(10) (max. 6.2, min. 2.2) and 1.1 log(10) (max. 2.1, min. 0) (Z = -5.766, P = 0.0000), respectively. At Week 48 they were 4.1 log(10) (max. 7.4, min. 1.0) and 2.3 log(10) (max. 7.5, min. 0.3) (Z = -2.760, P = 0.006), respectively. For intrahepatic HBV DNA load they were 1.3 log(10) (max. 4.3, min. -1.2) and 0.6 log(10) (max. 3.5, min. -0.8), respectively, and for HBV cccDNA load they were 1.1 log(10) (max. 4.8, min. -0.5) and 0.5 log(10) (max. 3.0, min. -0.8) (Z = -2.097, P = 0.036), respectively at Week 48. Step-wise logistic regression analysis indicated that the baseline intrahepatic HBV DNA load effected virological response at Week 12 [odds ratio (OR) 0.405; 95% confidence interval (CI) 0.174-0.944; P = 0.036] and HBeAg seroconversion at Week 48 (OR 0.292; 95% CI 0.131-0.649; P = 0.003). In conclusion, virological response at Week 12 indicated a great reduction of intrahepatic DNA and cccDNA load in HBeAg-positive CHB patients. The baseline intrahepatic HBV DNA load affected virological response at Week 12 and HBeAg seroconversion at Week 48.

语种英语
所属项目编号H020920020690 ; 2008ZX10002-004
资助者Beijing Municipal Science and Technology Commission ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Beijing Municipal Science and Technology Commission ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000275184400010
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51604
专题北京大学第一临床医学院_感染疾病科
作者单位1.Bejing Ditan Hosp, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Lu, H. Y.,Zhuang, L. W.,Yu, Y. Y.,et al. Virological response to antiviral therapy at week 12 indicates a great reduction of intrahepatic hepatitis B virus DNA and cccDNA in HBeAg-positive chronic hepatitis B patients[J]. JOURNAL OF VIRAL HEPATITIS,2010,suppl.1:59-65.
APA Lu, H. Y.,Zhuang, L. W.,Yu, Y. Y.,&Si, C. W..(2010).Virological response to antiviral therapy at week 12 indicates a great reduction of intrahepatic hepatitis B virus DNA and cccDNA in HBeAg-positive chronic hepatitis B patients.JOURNAL OF VIRAL HEPATITIS,suppl.1,59-65.
MLA Lu, H. Y.,et al."Virological response to antiviral therapy at week 12 indicates a great reduction of intrahepatic hepatitis B virus DNA and cccDNA in HBeAg-positive chronic hepatitis B patients".JOURNAL OF VIRAL HEPATITIS suppl.1(2010):59-65.
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