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学科主题: 临床医学
题名:
Virological response to antiviral therapy at week 12 indicates a great reduction of intrahepatic hepatitis B virus DNA and cccDNA in HBeAg-positive chronic hepatitis B patients
作者: Lu, H. Y.1; Zhuang, L. W.2; Yu, Y. Y.1; Si, C. W.1
关键词: covalently closed circular DNA ; hepatitis B virus ; interferon-alpha 2b ; lamivudine ; virological response
刊名: JOURNAL OF VIRAL HEPATITIS
发表日期: 2010-03-01
DOI: 10.1111/j.1365-2893.2010.01272.x
卷: suppl.1, 页:59-65
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]: CLOSED CIRCULAR DNA ; ADEFOVIR DIPIVOXIL ; PEGINTERFERON ALPHA-2A ; LAMIVUDINE THERAPY ; ENTECAVIR ; MANAGEMENT ; COMBINATION ; PERSISTENCE ; WORKSHOP ; ROADMAP
英文摘要:

Early virological response is considered to be a predictor for the outcome of anti-hepatitis B virus (HBV) therapy. To analyze its correlation to intrahepatic HBV DNA and covalently closed circular DNA (ccc)DNA, 71 hepatitis B virus e antigen (HBeAg)-positive chronic hepatitis B patients were recruited: 34 patients were treated with lamivudine; 13 with interferon-alpha 2b; and 24 with sequential therapy of lamivudine-interferon-alpha 2b for 48 weeks. Intrahepatic HBV DNA and cccDNA load were measured at the baseline and at Week 48. Fifty-seven patients had virological response at Week 12. Median decreases of serum HBV DNA in patients with or without virological response at Week 12 were 4.0 log(10) (max. 6.2, min. 2.2) and 1.1 log(10) (max. 2.1, min. 0) (Z = -5.766, P = 0.0000), respectively. At Week 48 they were 4.1 log(10) (max. 7.4, min. 1.0) and 2.3 log(10) (max. 7.5, min. 0.3) (Z = -2.760, P = 0.006), respectively. For intrahepatic HBV DNA load they were 1.3 log(10) (max. 4.3, min. -1.2) and 0.6 log(10) (max. 3.5, min. -0.8), respectively, and for HBV cccDNA load they were 1.1 log(10) (max. 4.8, min. -0.5) and 0.5 log(10) (max. 3.0, min. -0.8) (Z = -2.097, P = 0.036), respectively at Week 48. Step-wise logistic regression analysis indicated that the baseline intrahepatic HBV DNA load effected virological response at Week 12 [odds ratio (OR) 0.405; 95% confidence interval (CI) 0.174-0.944; P = 0.036] and HBeAg seroconversion at Week 48 (OR 0.292; 95% CI 0.131-0.649; P = 0.003). In conclusion, virological response at Week 12 indicated a great reduction of intrahepatic DNA and cccDNA load in HBeAg-positive CHB patients. The baseline intrahepatic HBV DNA load affected virological response at Week 12 and HBeAg seroconversion at Week 48.

语种: 英语
所属项目编号: H020920020690 ; 2008ZX10002-004
项目资助者: Beijing Municipal Science and Technology Commission ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000275184400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51604
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Bejing Ditan Hosp, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China

Recommended Citation:
Lu, H. Y.,Zhuang, L. W.,Yu, Y. Y.,et al. Virological response to antiviral therapy at week 12 indicates a great reduction of intrahepatic hepatitis B virus DNA and cccDNA in HBeAg-positive chronic hepatitis B patients[J]. JOURNAL OF VIRAL HEPATITIS,2010,suppl.1:59-65.
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