北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 药理学系  > 期刊论文
学科主题: 基础医学
题名:
Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system
作者: Zhao, X; Cui, XY; Chen, BQ; Chu, QP; Yao, HY; Ku, BS; Zhang, YH
关键词: tetrandrine ; sleep ; pentobarbital ; 5-hydroxytryptophan ; serotonergic system
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2004-12-15
DOI: 10.1016/j.ejphar.2004.10.046
卷: 506, 期:2, 页:101-105
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PARA-CHLOROPHENYLALANINE ; SLEEP ; RAT ; MECHANISMS ; NIFEDIPINE ; CYCLE ; 5-HYDROXYTRYPTOPHAN ; RECEPTORS ; EFFICACY ; STATES
英文摘要:

This is the first study of hypnotic activity of tetrandrine (a major component of Stephania tetrandrae) in mice by using synergism with pentobarbital as an index for the hypnotic effect. The results showed that tetrandrine potentiated pentobarbital (45 mg/kg, i.p.)-induced hypnosis significantly by reducing sleep latency and increasing sleeping time in a dose-dependent manner, and this effect was potentiated by 5-hydroxytryptophan (5-HTP). In the subhypnotic dosage of pentobarbital (28 mg/kg, i.p.)-treated mice, tetrandrine (60 and 30 mg/kg, p.o.) significantly increased the rate of sleep onset and also showed synergic effect with 5-HTP. Pretreatment of p-chlorophenylalanine (PCPA, 300 mg/kg, s.c.), an inhibitor of tryptophan hydroxylase, significantly decreased pentobarbital-induced sleeping time and tetrandrine abolished this effect. From these results, it should be presumed that serotonergic system may be involved in the augmentative effect of tetrandrine on pentobarbital-induced sleep. (C) 2004 Elsevier B.V All rights reserved.

语种: 英语
WOS记录号: WOS:000225761600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51608
Appears in Collections:基础医学院_药理学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Zhao, X,Cui, XY,Chen, BQ,et al. Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2004,506(2):101-105.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, X]'s Articles
[Cui, XY]'s Articles
[Chen, BQ]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, X]‘s Articles
[Cui, XY]‘s Articles
[Chen, BQ]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace