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学科主题基础医学
Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system
Zhao, X; Cui, XY; Chen, BQ; Chu, QP; Yao, HY; Ku, BS; Zhang, YH
关键词Tetrandrine Sleep Pentobarbital 5-hydroxytryptophan Serotonergic System
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2004-12-15
DOI10.1016/j.ejphar.2004.10.046
506期:2页:101-105
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PARA-CHLOROPHENYLALANINE ; SLEEP ; RAT ; MECHANISMS ; NIFEDIPINE ; CYCLE ; 5-HYDROXYTRYPTOPHAN ; RECEPTORS ; EFFICACY ; STATES
英文摘要

This is the first study of hypnotic activity of tetrandrine (a major component of Stephania tetrandrae) in mice by using synergism with pentobarbital as an index for the hypnotic effect. The results showed that tetrandrine potentiated pentobarbital (45 mg/kg, i.p.)-induced hypnosis significantly by reducing sleep latency and increasing sleeping time in a dose-dependent manner, and this effect was potentiated by 5-hydroxytryptophan (5-HTP). In the subhypnotic dosage of pentobarbital (28 mg/kg, i.p.)-treated mice, tetrandrine (60 and 30 mg/kg, p.o.) significantly increased the rate of sleep onset and also showed synergic effect with 5-HTP. Pretreatment of p-chlorophenylalanine (PCPA, 300 mg/kg, s.c.), an inhibitor of tryptophan hydroxylase, significantly decreased pentobarbital-induced sleeping time and tetrandrine abolished this effect. From these results, it should be presumed that serotonergic system may be involved in the augmentative effect of tetrandrine on pentobarbital-induced sleep. (C) 2004 Elsevier B.V All rights reserved.

语种英语
WOS记录号WOS:000225761600002
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51608
专题北京大学基础医学院_药理学系
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
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GB/T 7714
Zhao, X,Cui, XY,Chen, BQ,et al. Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2004,506(2):101-105.
APA Zhao, X.,Cui, XY.,Chen, BQ.,Chu, QP.,Yao, HY.,...&Zhang, YH.(2004).Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system.EUROPEAN JOURNAL OF PHARMACOLOGY,506(2),101-105.
MLA Zhao, X,et al."Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system".EUROPEAN JOURNAL OF PHARMACOLOGY 506.2(2004):101-105.
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