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学科主题: 临床医学
题名:
Oral Calcitriol for Reduction of Proteinuria in Patients With IgA Nephropathy: A Randomized Controlled Trial
作者: Liu, Li-Jun; Lv, Ji-Cheng; Shi, Su-Fang; Chen, Yu-Qing; Zhang, Hong; Wang, Hai-Yan
关键词: Immunoglobulin A (IgA) nephropathy ; proteinuria ; calcitriol ; renin-angiotensin system
刊名: AMERICAN JOURNAL OF KIDNEY DISEASES
发表日期: 2012
DOI: 10.1053/j.ajkd.2011.09.014
卷: 59, 期:1, 页:67-74
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; IMMUNOGLOBULIN-A NEPHROPATHY ; VITAMIN-D ANALOG ; TERM-FOLLOW-UP ; 1,25-DIHYDROXYVITAMIN D-3 ; COMBINATION THERAPY ; RENAL INFLAMMATION ; NATURAL-HISTORY ; PARICALCITOL ; CHINESE
英文摘要:

Background: Vitamin D has shown efficacy in the reduction of proteinuria in patients with chronic kidney disease. This study aimed to determine the effect of calcitriol on urinary protein excretion in patients with immunoglobulin A (IgA) nephropathy.

Study Design: Open-label, non-placebo-controlled, randomized study.

Setting & Participants: 50 patients with IgA nephropathy were enrolled. The main criterion for inclusion was urinary protein excretion >0.8 g/d after renin-angiotensin system-inhibitor treatment for at least 3 months.

Intervention: Patients were randomly assigned (1: 1) to receive 2 doses (0.5 mu g) of calcitriol per week or no treatment for 48 weeks.

Outcomes: The primary end point was to compare change in 24-hour urinary protein excretion from baseline to last measurement during treatment.

Measurements: Every 8 weeks, there was measurement of 24-hour urinary protein excretion, serum calcium, serum phosphorus, serum creatinine, and intact parathyroid hormone.

Results: Measurement of the primary end point showed changes in urinary protein excretion of +21% (from 1.29 to 1.58 g/24 h; 95% CI, -9% to +52%) in the control group and -19% (from 1.60 to 1.30 g/24 h; 95% CI, -42% to +4%) in the calcitriol-treated group. There was a significant decrease in proteinuria in the calcitriol-treated group compared with the control group (difference between groups, 41%; 95% CI, 5%-79%; P = 0.03). The secondary end point of achieving at least a 15% decrease in proteinuria was attained by 7 of 24 (29%) controls and 17 of 26 (65%) of those treated with calcitriol (P = 0.02). No significant differences were observed in decrease in estimated glomerular filtration rate and change in blood pressure between the 2 groups. The incidence of recorded adverse events was similar between the 2 groups.

Limitations: Small and non-placebo-controlled study.

Conclusions: The addition of calcitriol to a renin-angiotensin system inhibitor resulted in a safe decrease in proteinuria in patients with IgA nephropathy. Am J Kidney Dis. 59(1): 67-74. (C) 2011 by the National Kidney Foundation, Inc.

语种: 英语
WOS记录号: WOS:000298153600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51609
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Div Renal, Peking Univ Hosp 1, Inst Nephrol,Key Lab Renal Dis,Minist Hlth China, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Li-Jun,Lv, Ji-Cheng,Shi, Su-Fang,et al. Oral Calcitriol for Reduction of Proteinuria in Patients With IgA Nephropathy: A Randomized Controlled Trial[J]. AMERICAN JOURNAL OF KIDNEY DISEASES,2012,59(1):67-74.
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