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学科主题: 临床医学
题名:
CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL
作者: Kong, Y.2,3; Yoshida, S.2; Saito, Y.1; Doi, T.1; Nagatoshi, Y.4; Fukata, M.2; Saito, N.2; Yang, S. M.3; Iwamoto, C.2; Okamura, J.4; Liu, K. Y.3; Huang, X. J.3; Lu, D. P.3; Shultz, L. D.5; Harada, M.1; Ishikawa, F.1
关键词: acute lymphocytic leukemia ; stem cells ; transplantation
刊名: LEUKEMIA
发表日期: 2008-06-01
DOI: 10.1038/leu.2008.83
卷: 22, 期:6, 页:1207-1213
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: ACUTE LYMPHOBLASTIC-LEUKEMIA ; PRIMITIVE HEMATOPOIETIC-CELL ; ACUTE MYELOID-LEUKEMIA ; STEM-CELLS ; MICE ; IDENTIFICATION
英文摘要:

The presence of rare malignant stem cells supplying a hierarchy of malignant cells has recently been reported. In human acute myelogenous leukemia (AML), the leukemia stem cells (LSCs) have been phenotypically restricted within the CD34+CD38- fraction. To understand the origin of malignant cells in primary human B-precursor acute lymphocytic leukemia (B-ALL), we established a novel in vivo xenotransplantation model. Purified CD34+CD38+CD19+, CD34+CD38-CD19+ and CD34+CD38-CD19- bone marrow ( BM) or peripheral blood (PB) cells from three pediatric B-ALL patients were intravenously injected into sublethally irradiated newborn NOD/SCID/IL2r gamma(null) mice. We found that both CD34+CD38+CD19+ and CD34+CD38-CD19+ cells initiate B-ALL in primary recipients, whereas the recipients of CD34+CD38-CD10-CD19- cells showed normal human hematopoietic repopulation. The extent of leukemic infiltration into the spleen, liver and kidney was similar between the recipients transplanted with CD34+CD38+CD19+ cells and those transplanted with CD34+CD38-CD19+ cells. In each of the three cases studied, transplantation of CD34+CD38+CD19+ cells resulted in the development of B-ALL in secondary recipients, demonstrating self-renewal capacity. The identification of CD34+CD38+ CD19+ self-renewing B-ALL cells proposes a hierarchy of leukemia-initiating cells (LICs) distinct from that of AML. Recapitulation of patient B-ALL in NOD/SCID/IL2r gamma(null) recipients provides a powerful tool for directly studying leukemogenesis and for developing therapeutic strategies.

语种: 英语
WOS记录号: WOS:000256618900016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51616
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.RIKEN RCAI, Res Unit Human Dis Models, Tsurumi Ku, Kanagawa 2300045, Japan
2.Kyushu Univ, Grad Sch Med Sci, Dept Med & Biosyst Sci, Fukuoka 812, Japan
3.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China
4.Kyushu Natl Canc Ctr, Dept Pediat, Fukuoka, Japan
5.Jackson Lab, Bar Harbor, ME 04609 USA

Recommended Citation:
Kong, Y.,Yoshida, S.,Saito, Y.,et al. CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL[J]. LEUKEMIA,2008,22(6):1207-1213.
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