IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia
Qiu, X.1,2; Sun, X.3; He, Z.1; Huang, J.2; Hu, F.2; Chen, L.4; Lin, P.1; You, M. J.1; Medeiros, L. J.1; Yin, C. C.1
关键词IgG acute myeloid leukemia V(H)DJ(H) gene rearrangements
刊名LEUKEMIA
2013
DOI10.1038/leu.2012.184
27期:1页:92-99
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]EPITHELIAL CANCER-CELLS ; INTERNAL TANDEM DUPLICATION ; MYELOGENOUS LEUKEMIA ; TUMOR-CELLS ; REARRANGEMENT ; MUTATION ; LINES
英文摘要

Expression of immunoglobulin (Ig), a marker characteristic of B cells, has been reported in epithelial cells and has been suggested to have a role in their survival and growth. We assessed the frequency and level of Ig gamma heavy chain (IgG) expression in acute myeloid leukemia (AML), and found that IgG was expressed at a high frequency and level in AML cell lines and primary myeloblasts, but not in monocytes or neutrophils from patients with non-hematopoietic neoplasms or healthy controls. AML-derived IgG had the same molecular weight as B cell-derived IgG and was secreted. We further detected IgG V(H)DJ(H) transcripts in AML cell lines and sorted primary myeloblasts, confirming that IgG expression was indeed produced by AML cells. AML-derived IgG gene rearrangements showed evidence of somatic hypermutation of the variable (V) gene segments, and restricted (AML cell lines) or biased (primary myeloblasts) V usage. Anti-human IgG reduced cell viability and induced apoptosis in AML cell lines. Although the function of the AML-derived IgG is unclear, our findings suggest that AML-derived IgG may be a novel AML-related gene that contributes to leukemogenesis and AML progression. AML-derived IgG may serve as a useful molecular marker for monitoring minimal residual disease or designing target therapy. Leukemia (2013) 27, 92-99; doi:10.1038/leu.2012.184

语种英语
WOS记录号WOS:000313511400013
项目编号18079170 ; 30973389
资助机构University of Texas MD Anderson Cancer Center ; National Natural Science Foundation of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51623
专题北京大学基础医学院_免疫学系
作者单位1.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
2.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100871, Peoples R China
3.Univ Texas MD Anderson Canc Ctr, Dept Lab Med, Houston, TX 77030 USA
4.Univ Texas Houston, Sch Med, Dept Pathol, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Qiu, X.,Sun, X.,He, Z.,et al. Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia[J]. LEUKEMIA,2013,27(1):92-99.
APA Qiu, X..,Sun, X..,He, Z..,Huang, J..,Hu, F..,...&Yin, C. C..(2013).Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia.LEUKEMIA,27(1),92-99.
MLA Qiu, X.,et al."Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia".LEUKEMIA 27.1(2013):92-99.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
leu2012184a.pdf(1911KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qiu, X.]的文章
[Sun, X.]的文章
[He, Z.]的文章
百度学术
百度学术中相似的文章
[Qiu, X.]的文章
[Sun, X.]的文章
[He, Z.]的文章
必应学术
必应学术中相似的文章
[Qiu, X.]的文章
[Sun, X.]的文章
[He, Z.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: leu2012184a.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。