IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Prevalence of serum antibodies to TORCH among women before pregnancy or in the early period of pregnancy in Beijing
Li, Zhiyan; Yan, Cuiling; Liu, Ping; Yan, Rong; Feng, Zhenru
关键词Torch Clia Methodology Infective Rate
刊名CLINICA CHIMICA ACTA
2009-05-01
DOI10.1016/j.cca.2009.03.027
403期:1-2页:212-215
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]TRANSMISSION ; SIMPLEX
英文摘要

Background: The primary infection of Toxoplasma gondii (TOX), rubella virus (RV), cytomegalovirus (CMV), or herpes simplex virus (HSV), abbreviated as TORCH, remains a major problem in the pregnant women in China today.

Methods: We analyzed the performance of a novel chemiluminesent immunoassay (CLIA) for anti-TORCH IgM and IgG detection then analyzed the prevalence of TORCH infection among 4692 women at childbearing age in Beijing; China.

Results: The functional sensitivity of detecting anti-TOX IgM. anti-RV IgM, anti-CMV IgM and anti-HSV (types I and 2) IgM were 1.4, 3.2. 1.0 AU/ml and 0.5 index, respectively. The within-assay and the total CVs were both <10%, and recoveries of these assays ranged from 90-110%. High concentration of hemoglobin, lipids and bilirubin in sample did not affect the results. The infective rate of TORCH was 17.2%, with the highest positive rate of anti-HSV IgM. Within anti-TORCH IgG, anti-CMV IgG had the highest infective rate, 92.5%.

Conclusions: The infective rate of TORCH was fairly high among women before pregnancy or in the early period of pregnancy in Beijing. Entirely new approaches to prevention and treatment of congenital TORCH infection are necessary. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000266190100041
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51624
Collection北京大学第一临床医学院
作者单位Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhiyan,Yan, Cuiling,Liu, Ping,et al. Prevalence of serum antibodies to TORCH among women before pregnancy or in the early period of pregnancy in Beijing[J]. CLINICA CHIMICA ACTA,2009,403(1-2):212-215.
APA Li, Zhiyan,Yan, Cuiling,Liu, Ping,Yan, Rong,&Feng, Zhenru.(2009).Prevalence of serum antibodies to TORCH among women before pregnancy or in the early period of pregnancy in Beijing.CLINICA CHIMICA ACTA,403(1-2),212-215.
MLA Li, Zhiyan,et al."Prevalence of serum antibodies to TORCH among women before pregnancy or in the early period of pregnancy in Beijing".CLINICA CHIMICA ACTA 403.1-2(2009):212-215.
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