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学科主题: 临床医学
题名:
Penehyclidine hydrochloride ameliorates renal ischemia-reperfusion injury in rats
作者: Wang, Yun-peng1; Li, Gang1; Ma, Lu-lin1; Zheng, Yi1; Zhang, Shu-dong1; Zhang, Hong-xian1; Qiu, Min1; Ma, Xin2
关键词: Penehyclidine hydrochloride ; Kidney ; Ischemia-reperfusion injury ; Inflammation ; Oxidative stress ; Apoptosis
刊名: JOURNAL OF SURGICAL RESEARCH
发表日期: 2014
DOI: 10.1016/j.jss.2013.07.041
卷: 186, 期:1, 页:390-397
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; KAPPA-B ; ISCHEMIA/REPERFUSION INJURY ; ALZHEIMERS-DISEASE ; OPTICAL ISOMERS ; MAP KINASE ; RECEPTORS ; CELLS ; P38 ; APOPTOSIS
英文摘要:

Background: Renal ischemiaereperfusion (I/R) injury is a major cause of acute kidney failure by mechanisms that involve oxidative stress, inflammation, and apoptosis. Penehyclidine hydrochloride (PHC), a selective anticholinergic agent, possesses anti-inflammatory, anti-oxidative stress, and antiapoptotic effects. Therefore, we investigated the ability of PHC to ameliorate renal I/R injury in Sprague-Dawley rats.

Materials and methods: Rats were randomly assigned to three groups (35 rats per group): sham operated, saline-treated I/R, and PHC-treated I/R. After removing the right kidney, renal I/R injury was induced by clamping the left renal artery for 45 min followed by reperfusion. The rats were administered PHC (0.45 mg/kg, intravenously) or saline 30 min before renal ischemia. The blood and kidneys were harvested at 1, 3, 6, 12, or 24 h after reperfusion. Renal function and histologic changes were assessed. Markers of oxidative stress, inflammation, and apoptosis in the kidneys were also measured.

Results: PHC treatment significantly attenuated renal dysfunction and histologic damage caused by I/R injury. The treatment also decreased malondialdehyde level and attenuated the reduction in superoxide dismutase activity in the kidney. Moreover, the levels of activated p38 mitogen-activated protein kinase, nuclear factor kappa B, and caspase 3 were lower in the PHC-treated animals.

Conclusions: PHC protected rat kidneys from I/R injury by attenuating oxidative stress, inflammatory response, and apoptosis. Thus, PHC may represent a novel practical strategy for the treatment of renal I/R injury. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30950018 ; 7113174
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000328628800064
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51626
Appears in Collections:北京大学第三临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Sch Basic Med Sci, Dept Biol, Beijing 100029, Peoples R China

Recommended Citation:
Wang, Yun-peng,Li, Gang,Ma, Lu-lin,et al. Penehyclidine hydrochloride ameliorates renal ischemia-reperfusion injury in rats[J]. JOURNAL OF SURGICAL RESEARCH,2014,186(1):390-397.
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