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All-trans retinoic acid regulates c-jun expression via ERK5 in cardiac myoblasts
Ren, Xia1; Ma, Xi2; Li, Yong1
关键词All-trans Retinoic Acid Erk5 Erk1 C-jun Translocation Proliferation
刊名JOURNAL OF NUTRITIONAL BIOCHEMISTRY
2007-12-01
DOI10.1016/j.jnutbio.2006.12.023
18期:12页:832-838
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Nutrition & Dietetics
研究领域[WOS]Biochemistry & Molecular Biology ; Nutrition & Dietetics
关键词[WOS]SIGNAL-TRANSDUCTION ; MAP KINASE ; CELL-PROLIFERATION ; TRANSCRIPTION FACTOR ; INDUCED APOPTOSIS ; GENE-EXPRESSION ; PATHWAY ; BMK1/ERK5 ; BINDING ; BMK1
英文摘要

Retinoic acid (RA) is an active metabolite of vitamin A and plays an important role in biological processes including cell proliferation. MAPKs play a pivotal role in regulating many critical cellular processes in the heart. The aim of the study was to determine whether all-trans RA (atRA) affects the proliferation of H9c2 rat ventricular cells and whether ERK family is involved in this process. H9c2 myocardial cells were cultured and subjected to MTT and H-3-thymidine incorporation assays for proliferation detection. Luciferase reporter gene and Western blot assays were used to detect the transcription and protein expression of c-jun. In addition, the activities of EPK5 and ERK1 were determined by Western blot assay. The subcellular distribution of ERK5 and ERK1 was analyzed by confocal microscopy. It was shown that atRA (0.05 mu M) facilitated the proliferation of H9c2 myocardial cells and increased the transcription and protein expression of c-jun. Inhibition of ERK5 significantly decreased atRA-induced pJluc expression (P <.01). The activity of ERK5 but not ERK1 was induced by atRA. Furthermore, atRA promoted the nuclear translocation of ERK5 but not ERK1. These results suggest that ERK5 pathway may be involved in the process that atRA regulates proliferation in the developing heart. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000251701800009
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51635
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Lab Dev Mol Biol,Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
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Ren, Xia,Ma, Xi,Li, Yong. All-trans retinoic acid regulates c-jun expression via ERK5 in cardiac myoblasts[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2007,18(12):832-838.
APA Ren, Xia,Ma, Xi,&Li, Yong.(2007).All-trans retinoic acid regulates c-jun expression via ERK5 in cardiac myoblasts.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,18(12),832-838.
MLA Ren, Xia,et al."All-trans retinoic acid regulates c-jun expression via ERK5 in cardiac myoblasts".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 18.12(2007):832-838.
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