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学科主题口腔医学
PTCH1 mutations in odontogenic keratocysts: Are they related to epithelial cell proliferation?
Pan, Shuang; Li, Tie-Jun
关键词Ptch1 Odontogenic Keratocyst Nevoid Basal Cell Carcinoma Syndrome Ki67 Cell Proliferation
刊名ORAL ONCOLOGY
2009-10-01
DOI10.1016/j.oraloncology.2009.02.003
45期:10页:861-865
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
资助者National Nature Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Nature Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
关键词[WOS]CARCINOMA SYNDROME ; GERMLINE MUTATIONS ; GORLIN-SYNDROME ; GENE-MUTATIONS ; HEDGEHOG ; PATHWAY ; EXPRESSION ; PROTEIN ; APOPTOSIS ; LESIONS
英文摘要

Mutations in PTCH1 gene are responsible for majority of nevoid basal cell carcinoma syndrome (NBCCS) as well as for some related sporadic neoplasms. Odontogenic keratocysts (OKCs) are locally aggressive jaw lesions that may occur in isolation or in association with NBCCS. Mutations of PTCH1 would lead to constitutive activation of Sonic hedgehog (SHH) signaling pathway and result in aberrant cell proliferation. To clarify the role of PTCH1 in OKCs, mutational analysis was undertaken in eight sporadic and four NBCCS- associated OKCs and six PTCH1 mutations were identified in two sporadic and three NBCCS- associated cases. The epithelial cell proliferation as assessed by Ki67 labeling was studied in a total cohort of 62 OKCs (42 sporadic and 20 syndromic cases) with known PTCH1 status. The epithelial Ki67 labeling in OKCs with PTCH1 mutation was significantly higher than that in cases with no PTCH1 mutation. Furthermore, OKCs harboring PTCH1 truncation-causing mutations showed an even greater Ki67 labeling index than those with non-truncation-causing mutations. These results suggest that PTCH1 mutations, particularly those causing protein truncations, are associated with a subgroup of OKCs showing increased proliferative activity and thus may relate to a phenotype of higher recurrent tendency. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号30625044 ; 30572048 ; 30872900 ; 20050001110
资助者National Nature Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Nature Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000270022000004
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51639
专题北京大学口腔医学院_口腔病理科
作者单位Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Pan, Shuang,Li, Tie-Jun. PTCH1 mutations in odontogenic keratocysts: Are they related to epithelial cell proliferation?[J]. ORAL ONCOLOGY,2009,45(10):861-865.
APA Pan, Shuang,&Li, Tie-Jun.(2009).PTCH1 mutations in odontogenic keratocysts: Are they related to epithelial cell proliferation?.ORAL ONCOLOGY,45(10),861-865.
MLA Pan, Shuang,et al."PTCH1 mutations in odontogenic keratocysts: Are they related to epithelial cell proliferation?".ORAL ONCOLOGY 45.10(2009):861-865.
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