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学科主题: 口腔医学
题名:
PTCH1 mutations in odontogenic keratocysts: Are they related to epithelial cell proliferation?
作者: Pan, Shuang; Li, Tie-Jun
关键词: PTCH1 ; Odontogenic keratocyst ; Nevoid basal cell carcinoma syndrome ; Ki67 ; Cell proliferation
刊名: ORAL ONCOLOGY
发表日期: 2009-10-01
DOI: 10.1016/j.oraloncology.2009.02.003
卷: 45, 期:10, 页:861-865
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Oncology ; Dentistry, Oral Surgery & Medicine
关键词[WOS]: CARCINOMA SYNDROME ; GERMLINE MUTATIONS ; GORLIN-SYNDROME ; GENE-MUTATIONS ; HEDGEHOG ; PATHWAY ; EXPRESSION ; PROTEIN ; APOPTOSIS ; LESIONS
英文摘要:

Mutations in PTCH1 gene are responsible for majority of nevoid basal cell carcinoma syndrome (NBCCS) as well as for some related sporadic neoplasms. Odontogenic keratocysts (OKCs) are locally aggressive jaw lesions that may occur in isolation or in association with NBCCS. Mutations of PTCH1 would lead to constitutive activation of Sonic hedgehog (SHH) signaling pathway and result in aberrant cell proliferation. To clarify the role of PTCH1 in OKCs, mutational analysis was undertaken in eight sporadic and four NBCCS- associated OKCs and six PTCH1 mutations were identified in two sporadic and three NBCCS- associated cases. The epithelial cell proliferation as assessed by Ki67 labeling was studied in a total cohort of 62 OKCs (42 sporadic and 20 syndromic cases) with known PTCH1 status. The epithelial Ki67 labeling in OKCs with PTCH1 mutation was significantly higher than that in cases with no PTCH1 mutation. Furthermore, OKCs harboring PTCH1 truncation-causing mutations showed an even greater Ki67 labeling index than those with non-truncation-causing mutations. These results suggest that PTCH1 mutations, particularly those causing protein truncations, are associated with a subgroup of OKCs showing increased proliferative activity and thus may relate to a phenotype of higher recurrent tendency. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30625044 ; 30572048 ; 30872900 ; 20050001110
项目资助者: National Nature Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000270022000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51639
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Pan, Shuang,Li, Tie-Jun. PTCH1 mutations in odontogenic keratocysts: Are they related to epithelial cell proliferation?[J]. ORAL ONCOLOGY,2009,45(10):861-865.
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