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学科主题临床医学
The in vitro activity of sulbactam combined with third generation cephalosporins against third generation cephalosporin-resistant bacteria
Zhang, YL; Li, JT
关键词Cefuroxime Cefotaxime Ceftazidime Sulbactam In Vitro Antibacterial Activity
刊名INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
2001-02-01
17期:2页:143-146
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]BETA-LACTAM ANTIBIOTICS ; GRAM-NEGATIVE BACTERIA ; STEADY-STATE TREATMENT ; QUANTITATIVE RELATIONSHIP ; SENSITIVITY ; BACILLI
英文摘要

The in vitro activity of the beta -lactamase inhibitor sulbactam combined with cefuroxime, cefotaxime or ceftazidime in the ratio of 1:1 was studied against ceftazidime- or cefuroxime-resistant Gram-negative rods and Staphylococcus aureus. Sulbactam enhanced the antibacterial activities of cefuroxime, cefotaxime and ceftazidime against Gram-negative rods. The MIG,, of ceftazidime against Escherichia coli, Enterobacter cloacae, Citrobacter freundii and Acinetobacter spp. reduced by 2-4 fold. was reduced 4-fold and that of cefotaxime against E. coli, E. cloacae, C. freundii and Acinetobacter spp. reduced by 2-3-fold. However, sulbactam did not enhance the activities of cefuroxime, cefotaxime or ceftazidime against S. aureus, enterococci and Stenotrophomonas maltophilia. With the combination of sulbactam and ceftazidime at the ratio of 1:1, 38.4% of E. coli, 45.3% of E. cloacae, 66.6% of C. freundii and 60% of Acinetobacter spp. initially resistant to ceftazidime became susceptible. (C) 2001 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

语种英语
WOS记录号WOS:000166851000010
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51648
专题北京大学第一临床医学院_临床药理研究所
北京大学精神卫生研究所_精神科
作者单位Beijing Med Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, YL,Li, JT. The in vitro activity of sulbactam combined with third generation cephalosporins against third generation cephalosporin-resistant bacteria[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2001,17(2):143-146.
APA Zhang, YL,&Li, JT.(2001).The in vitro activity of sulbactam combined with third generation cephalosporins against third generation cephalosporin-resistant bacteria.INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,17(2),143-146.
MLA Zhang, YL,et al."The in vitro activity of sulbactam combined with third generation cephalosporins against third generation cephalosporin-resistant bacteria".INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 17.2(2001):143-146.
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