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学科主题: 临床医学
题名:
The in vitro activity of sulbactam combined with third generation cephalosporins against third generation cephalosporin-resistant bacteria
作者: Zhang, YL; Li, JT
关键词: cefuroxime ; cefotaxime ; ceftazidime ; sulbactam ; in vitro antibacterial activity
刊名: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
发表日期: 2001-02-01
卷: 17, 期:2, 页:143-146
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: BETA-LACTAM ANTIBIOTICS ; GRAM-NEGATIVE BACTERIA ; STEADY-STATE TREATMENT ; QUANTITATIVE RELATIONSHIP ; SENSITIVITY ; BACILLI
英文摘要:

The in vitro activity of the beta -lactamase inhibitor sulbactam combined with cefuroxime, cefotaxime or ceftazidime in the ratio of 1:1 was studied against ceftazidime- or cefuroxime-resistant Gram-negative rods and Staphylococcus aureus. Sulbactam enhanced the antibacterial activities of cefuroxime, cefotaxime and ceftazidime against Gram-negative rods. The MIG,, of ceftazidime against Escherichia coli, Enterobacter cloacae, Citrobacter freundii and Acinetobacter spp. reduced by 2-4 fold. was reduced 4-fold and that of cefotaxime against E. coli, E. cloacae, C. freundii and Acinetobacter spp. reduced by 2-3-fold. However, sulbactam did not enhance the activities of cefuroxime, cefotaxime or ceftazidime against S. aureus, enterococci and Stenotrophomonas maltophilia. With the combination of sulbactam and ceftazidime at the ratio of 1:1, 38.4% of E. coli, 45.3% of E. cloacae, 66.6% of C. freundii and 60% of Acinetobacter spp. initially resistant to ceftazidime became susceptible. (C) 2001 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

语种: 英语
WOS记录号: WOS:000166851000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51648
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: Beijing Med Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, YL,Li, JT. The in vitro activity of sulbactam combined with third generation cephalosporins against third generation cephalosporin-resistant bacteria[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2001,17(2):143-146.
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