IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Calcium Channel Autoantibodies Predicted Sudden Cardiac Death and All-Cause Mortality in Patients with Ischemic and Nonischemic Chronic Heart Failure
Yu, Haiyun1,2; Pei, Juanhui1,2; Liu, Xiaoyan1,2; Chen, Jingzhou1,2; Li, Xian1,2; Zhang, Yinhui1,2; Li, Ning1,2; Wang, Zengwu1,2; Zhang, Ping3; Cao, Kejiang4; Pu, Jielin1,2
刊名DISEASE MARKERS
2014
DOI10.1155/2014/796075
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental ; Pathology
资助者National Basic Research Program of China (973 program) ; National Basic Research Program of China (973 program)
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine ; Pathology
关键词[WOS]IDIOPATHIC DILATED CARDIOMYOPATHY ; NA-K-ATPASE ; BETA(1)-ADRENERGIC RECEPTORS ; VENTRICULAR-TACHYCARDIA ; CELLULAR DYSFUNCTION ; ARRHYTHMIAS ; ANTIBODIES ; TRIAL ; METAANALYSIS ; DILTIAZEM
英文摘要

The purpose of this study was to evaluate whether CC-AAbs levels could predict prognosis in CHF patients. A total of 2096 patients with CHF (841 DCM patients and 1255 ICM patients) and 834 control subjects were recruited. CC-AAbs were detected and the relationship between CC-AAbs and patient prognosis was analyzed. During a median follow-up time of 52 months, there were 578 deaths. Of these, sudden cardiac death (SCD) occurred in 102 cases of DCM and 121 cases of ICM. The presence of CC-AAbs in patients was significantly higher than that of controls (both P < 0.001). Multivariate analysis revealed that positive CC-AAbs could predict SCD (HR 3.191, 95% CI 1.598-6.369 for DCM; HR 2.805, 95% CI 1.488-5.288 for ICM) and all-cause mortality (HR 1.733, 95% CI 1.042-2.883 for DCM; HR 2.219, 95% CI 1.461-3.371 for ICM) in CHF patients. A significant association between CC-AAbs and non-SCD (NSCD) was found in ICM patients (HR = 1.887, 95% CI 1.081-3.293). Our results demonstrated that the presence of CC-AAbs was higher in CHF patients versus controls and corresponds to a higher incidence of all-cause death and SCD. Positive CC-AAbs may serve as an independent predictor for SCD and all-cause death in these patients.

语种英语
所属项目编号2013CB531105
资助者National Basic Research Program of China (973 program) ; National Basic Research Program of China (973 program)
WOS记录号WOS:000333172600001
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51654
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Chinese Acad Med Sci, Physiol & Pathophysiol Lab, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis,Fu Wai Cardiovasc Hosp, Beijing 100037, Peoples R China
3.Peking Union Med Coll, Beijing 100037, Peoples R China
4.First Peoples Hosp Jiangsu Prov, Nanjing 210029, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Yu, Haiyun,Pei, Juanhui,Liu, Xiaoyan,et al. Calcium Channel Autoantibodies Predicted Sudden Cardiac Death and All-Cause Mortality in Patients with Ischemic and Nonischemic Chronic Heart Failure[J]. DISEASE MARKERS,2014.
APA Yu, Haiyun.,Pei, Juanhui.,Liu, Xiaoyan.,Chen, Jingzhou.,Li, Xian.,...&Pu, Jielin.(2014).Calcium Channel Autoantibodies Predicted Sudden Cardiac Death and All-Cause Mortality in Patients with Ischemic and Nonischemic Chronic Heart Failure.DISEASE MARKERS.
MLA Yu, Haiyun,et al."Calcium Channel Autoantibodies Predicted Sudden Cardiac Death and All-Cause Mortality in Patients with Ischemic and Nonischemic Chronic Heart Failure".DISEASE MARKERS (2014).
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