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Investigation on the Interaction Between Anthracyclines and DNA in the Presence of Quercetin by Resonance Light Scattering Technique and Its Analytical Application
Chen, Zhanguang1; Qian, Sihua1; Chen, Xi2; Chen, Junhui3; Zhang, Guomin1; Zhong, Huiling1
关键词Circular Dichroism Spectroscopy Dna Detection Doxorubicin Epirubicin Interaction Mitoxantrone Quercetin Resonance Light Scattering Ultraviolet Visible Spectroscopy
刊名CURRENT ANALYTICAL CHEMISTRY
2013
9期:1页:135-142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical
资助者Guangdong Science and Technology Department ; Science Foundation of Shantou University ; Guangdong Science and Technology Department ; Science Foundation of Shantou University
研究领域[WOS]Chemistry
关键词[WOS]FLOW-INJECTION ANALYSIS ; NUCLEIC-ACIDS ; ANTIOXIDANT ACTIVITY ; RAYLEIGH-SCATTERING ; HUMAN SERUM ; AGGREGATION ; ASSAY ; CARDIOTOXICITY ; ASSEMBLIES ; MECHANISMS
英文摘要

Resonance light scattering technique has been employed to investigate the interaction between anthracyclines and DNA in the presence of quercetin. Upon binding to DNA, anthracyclines undergo dramatic enhancement in their resonance light scattering intensities, while quercetin goes through no obvious change in its intensity. Once being added into anthracyclines-DNA system, quercetin can induce great difference in resonance light scattering intensities between anthracyclines-DNA-quercetin ternary system and anthracyclines-DNA binary system. Consequently, the DNA binding abilities of anthracyclines can be improved by quercetin. Improved efficiency of quercetin on the interaction between anthracyclines and DNA has been calculated. Under the experimental condition, the improved efficiency values of doxorubicin, epirubicin and mitoxantrone were 38.78%, 28.53% and 16.69%, respectively. Additionally, the weak resonance light scattering intensity of quercetin-DNA system is greatly enhanced by anthracyclines and the enhanced intensity is proportional to the concentration of anthracyclines in the range 0.06-9.0 mu g mL(-1) for doxorubicin, 0.08-12 mu g mL(-1) for epirubicin and 0.01-3.0 mu g mL(-1) for mitoxantrone. The detection limits are 4.7 ng mL(-1) for doxorubicin, 5.4 ng mL(-1) for epirubicin and 1.4 ng mL(-1) for mitoxantrone.

语种英语
所属项目编号2006B35630009 ; YR09009
资助者Guangdong Science and Technology Department ; Science Foundation of Shantou University ; Guangdong Science and Technology Department ; Science Foundation of Shantou University
WOS记录号WOS:000314878800015
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51657
专题北京大学深圳医院
作者单位1.Shantou Univ, Dept Chem, Shantou 515063, Peoples R China
2.Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Intervent Oncol & Minimally Invas Therapies Dept, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Chen, Zhanguang,Qian, Sihua,Chen, Xi,et al. Investigation on the Interaction Between Anthracyclines and DNA in the Presence of Quercetin by Resonance Light Scattering Technique and Its Analytical Application[J]. CURRENT ANALYTICAL CHEMISTRY,2013,9(1):135-142.
APA Chen, Zhanguang,Qian, Sihua,Chen, Xi,Chen, Junhui,Zhang, Guomin,&Zhong, Huiling.(2013).Investigation on the Interaction Between Anthracyclines and DNA in the Presence of Quercetin by Resonance Light Scattering Technique and Its Analytical Application.CURRENT ANALYTICAL CHEMISTRY,9(1),135-142.
MLA Chen, Zhanguang,et al."Investigation on the Interaction Between Anthracyclines and DNA in the Presence of Quercetin by Resonance Light Scattering Technique and Its Analytical Application".CURRENT ANALYTICAL CHEMISTRY 9.1(2013):135-142.
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