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Synthesis and antibacterial activity of 4 ′′-O-heteroarylcarbamoyl derivatives of macrolide
Xu, Peng1; Liu, Lu1; Jin, Zhi-ping2; Wang, Guang-qiang2; Liu, Jian3; Li, Yun3; Lei, Ping-sheng1
关键词4 &Prime &Prime -modified Macrolide Synthesis Macrolide Resistance
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2008-10-15
DOI10.1016/j.bmcl.2008.09.022
18期:20页:5507-5511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]LARGE RIBOSOMAL-SUBUNIT ; RESPIRATORY PATHOGENS ; STRUCTURAL BASIS ; HIGHLY POTENT ; ANTIBIOTICS ; RESISTANCE ; KETOLIDES ; TELITHROMYCIN ; LINCOSAMIDE
英文摘要

A series of novel 4 ′′-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4 ′′-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria. (c) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000259972800038
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51661
专题北京大学第一临床医学院_临床药理研究所
北京大学口腔医学院_口腔预防保健科
作者单位1.Jingxin Pharmaceut Co, Xinchang 312400, Zhejiang, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Peking Univ, Inst Clin Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, Peng,Liu, Lu,Jin, Zhi-ping,et al. Synthesis and antibacterial activity of 4 ′′-O-heteroarylcarbamoyl derivatives of macrolide[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(20):5507-5511.
APA Xu, Peng.,Liu, Lu.,Jin, Zhi-ping.,Wang, Guang-qiang.,Liu, Jian.,...&Lei, Ping-sheng.(2008).Synthesis and antibacterial activity of 4 ′′-O-heteroarylcarbamoyl derivatives of macrolide.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(20),5507-5511.
MLA Xu, Peng,et al."Synthesis and antibacterial activity of 4 ′′-O-heteroarylcarbamoyl derivatives of macrolide".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.20(2008):5507-5511.
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