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Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer
Shi, Jiyun1,2,3; Liu, Tracy W. B.1,2; Chen, Juan2; Green, David2; Jaffray, David1,2; Wilson, Brian C.1,2; Wang, Fan3; Zheng, Gang1,2
关键词Copper-64 Porphyrin Pet Folate Receptor Peptides
刊名THERANOSTICS
2011
DOI10.7150/thno/v01p0363
1页:363-370
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; TUMOR-BEARING RATS ; PHOTODYNAMIC THERAPY ; RADIOTHERAPY ; RADIOPHARMACEUTICALS ; DOSIMETRY
英文摘要

Porphyrin based photosensitizers are useful agents for photodynamic therapy (PDT) and fluorescence imaging of cancer. Porphyrins are also excellent metal chelators forming highly stable metallo-complexes making them efficient delivery vehicles for radioisotopes. Here we investigated the possibility of incorporating (64)Cu into a porphyrin-peptide-folate (PPF) probe developed previously as folate receptor (FR) targeted fluorescent/PDT agent, and evaluated the potential of turning the resulting (64)Cu-PPF into a positron emission tomography (PET) probe for cancer imaging. Noninvasive PET imaging followed by radioassay evaluated the tumor accumulation, pharmacokinetics and biodistribution of (64)Cu-PPF. (64)Cu-PPF uptake in FR-positive tumors was visible on small-animal PET images with high tumor-to-muscle ratio (8.88 +/- 3.60) observed after 24 h. Competitive blocking studies confirmed the FR-mediated tracer uptake by the tumor. The ease of efficient (64)Cu-radiolabeling of PPF while retaining its favorable biodistribution, pharmacokinetics and selective tumor uptake, provides a robust strategy to transform tumor-targeted porphyrin-based photosensitizers into PET imaging probes.

语种英语
WOS记录号WOS:000299121000030
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被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51670
专题北京大学医药卫生分析中心
作者单位1.Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
2.Univ Hlth Network, Ontario Canc Inst, Toronto, ON, Canada
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China
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Shi, Jiyun,Liu, Tracy W. B.,Chen, Juan,et al. Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer[J]. THERANOSTICS,2011,1:363-370.
APA Shi, Jiyun.,Liu, Tracy W. B..,Chen, Juan.,Green, David.,Jaffray, David.,...&Zheng, Gang.(2011).Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer.THERANOSTICS,1,363-370.
MLA Shi, Jiyun,et al."Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer".THERANOSTICS 1(2011):363-370.
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