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学科主题: 公共卫生
题名:
Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer
作者: Shi, Jiyun1,2,3; Liu, Tracy W. B.1,2; Chen, Juan2; Green, David2; Jaffray, David1,2; Wilson, Brian C.1,2; Wang, Fan3; Zheng, Gang1,2
关键词: Copper-64 ; Porphyrin ; PET ; Folate receptor ; Peptides
刊名: THERANOSTICS
发表日期: 2011
DOI: 10.7150/thno/v01p0363
卷: 1, 页:363-370
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: POSITRON-EMISSION-TOMOGRAPHY ; TUMOR-BEARING RATS ; PHOTODYNAMIC THERAPY ; RADIOTHERAPY ; RADIOPHARMACEUTICALS ; DOSIMETRY
英文摘要:

Porphyrin based photosensitizers are useful agents for photodynamic therapy (PDT) and fluorescence imaging of cancer. Porphyrins are also excellent metal chelators forming highly stable metallo-complexes making them efficient delivery vehicles for radioisotopes. Here we investigated the possibility of incorporating (64)Cu into a porphyrin-peptide-folate (PPF) probe developed previously as folate receptor (FR) targeted fluorescent/PDT agent, and evaluated the potential of turning the resulting (64)Cu-PPF into a positron emission tomography (PET) probe for cancer imaging. Noninvasive PET imaging followed by radioassay evaluated the tumor accumulation, pharmacokinetics and biodistribution of (64)Cu-PPF. (64)Cu-PPF uptake in FR-positive tumors was visible on small-animal PET images with high tumor-to-muscle ratio (8.88 +/- 3.60) observed after 24 h. Competitive blocking studies confirmed the FR-mediated tracer uptake by the tumor. The ease of efficient (64)Cu-radiolabeling of PPF while retaining its favorable biodistribution, pharmacokinetics and selective tumor uptake, provides a robust strategy to transform tumor-targeted porphyrin-based photosensitizers into PET imaging probes.

语种: 英语
所属项目编号: W81XWH-10-1-0115 ; 2011CB707703 ; 30930030
项目资助者: DOD BCRP ; Natural Sciences and Engineering Research Council of Canada ; Canadian Foundation of Innovation, China ; NSFC ; Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research ; Ontario Institute for Cancer Research ; Canadian Institute of Health Research
WOS记录号: WOS:000299121000030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51670
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
2.Univ Hlth Network, Ontario Canc Inst, Toronto, ON, Canada
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Shi, Jiyun,Liu, Tracy W. B.,Chen, Juan,et al. Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer[J]. THERANOSTICS,2011,1:363-370.
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