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学科主题: 临床医学
题名:
Scaffolds drive meniscus tissue engineering
作者: Zhang, Zheng-Zheng1; Jiang, Dong1; Wang, Shao-Jie1; Qi, Yan-Song1; Ding, Jian-Xun2; Yu, Jia-Kuo1; Chen, Xue-Si2
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra13859k
卷: 5, 期:95, 页:77851-77859
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: ARTICULAR-CARTILAGE ; KNEE MENISCUS ; IN-VITRO ; NANOFIBROUS SCAFFOLDS ; SHEEP MODEL ; HYDROSTATIC-PRESSURE ; HYALURONIC-ACID ; REGENERATION ; CELLS ; REPAIR
英文摘要:

Meniscus injury is a common sports injury. The removal of the injured meniscus predisposes the development of osteoarthritis. Tissue engineering provides a promising approach for the treatment of meniscus injury. Over the past few decades, researchers have put a lot of effort in developing various kinds of scaffolds for preventing osteoarthritis and relieving clinical symptoms. The scaffolds for meniscus tissue engineering (MTE) can be categorized into four classes: hydrogels, three-dimensional (3D) porous polymeric scaffolds, extracellular matrix (ECM) macromolecule-based 3D matrices, and tissue-derived platforms. Although the expected efficacies in tissue integration and chondro-protective function have not yet emerged, several scaffolds have been exploited to provide new substitutes for native meniscus, suggesting their great potential in promoting tissue engineered meniscus (TEM). In the current review, we provide and discuss evidences on different scaffolds in order to make recommendations for the further development of MTE.

语种: 英语
所属项目编号: 51273004 ; 31200725 ; 51303174 ; 2012AA020502 ; 14KG045
项目资助者: National Natural Scientific Foundation of China ; National High Technology Research and Development Program of China (863 Program) ; Science and Technology Planning Project of Changchun City
WOS记录号: WOS:000361559900045
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51673
Appears in Collections:北京大学第三临床医学院_运动医学研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing Key Lab Sports Injuries, Inst Sports Med, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

Recommended Citation:
Zhang, Zheng-Zheng,Jiang, Dong,Wang, Shao-Jie,et al. Scaffolds drive meniscus tissue engineering[J]. RSC ADVANCES,2015,5(95):77851-77859.
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