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学科主题临床医学
Isolated duodenal myeloid sarcoma associated with the CBF beta/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review
Huang, Bo1; You, Peng2; Zhu, Ping1; Du, Zunguo3; Wu, Beiqian1; Xu, Xiaoping1; Chen, Zi1
关键词Cbf Beta/myh11 Fusion Gene Acute Myeloid Leukemia Myeloid Sarcoma
刊名ONCOLOGY LETTERS
2014-09-01
DOI10.3892/ol.2014.2313
8期:3页:1261-1264
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; Shanghai Municipal Health Bureau ; National Natural Science Foundation of China ; Shanghai Municipal Health Bureau
研究领域[WOS]Oncology
关键词[WOS]ACUTE MYELOMONOCYTIC LEUKEMIA ; GRANULOCYTIC SARCOMA ; SMALL-INTESTINE ; EOSINOPHILS ; INVERSION ; DIAGNOSIS ; CHLOROMA ; AML
英文摘要

Myeloid sarcoma (MS) is a rare disease that presents as an extramedullary tumorous mass of immature myeloid precursors. The majority of MS are identified in acute myeloid leukemia (AML) patients and rarely present as a primary isolated MS without AML. In addition, inversion of chromosome 16 [inv(16)] and the CBF beta/MYH11 fusion gene are rarely associated with MS. The current study reports a female patient with an isolated duodenal MS, who developed AML-M4 associated with the CBF beta/MYH11 fusion gene ana 48,XX,inv(16),+13,+22. A review of previously reported cases of isolated MS with the CBF beta/MYH11 fusion gene was also performed. Isolated MS with the CBF beta/MYH11 fusion gene was often observed in abdominal lesions, with the intestinal tract being the predominantly involved site. In addition, patients with isolated MS with the CBF beta/MYH11 fusion exhibited a high risk of developing systemic AML. The diagnosis of isolated MS may be particularly challenging and, therefore, determining the optimal standard treatment for isolated MS is required.

语种英语
所属项目编号NSFC 81170491 ; NSFC 81170357 ; 2010079
资助者National Natural Science Foundation of China ; Shanghai Municipal Health Bureau ; National Natural Science Foundation of China ; Shanghai Municipal Health Bureau
WOS记录号WOS:000340854600062
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51680
Collection北京大学第二临床医学院_消化科
作者单位1.Fudan Univ, Huashan Hosp, Dept Hematol, Shanghai 200040, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
3.Fudan Univ, Huashan Hosp, Dept Pathol, Shanghai 200040, Peoples R China
Recommended Citation
GB/T 7714
Huang, Bo,You, Peng,Zhu, Ping,et al. Isolated duodenal myeloid sarcoma associated with the CBF beta/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review[J]. ONCOLOGY LETTERS,2014,8(3):1261-1264.
APA Huang, Bo.,You, Peng.,Zhu, Ping.,Du, Zunguo.,Wu, Beiqian.,...&Chen, Zi.(2014).Isolated duodenal myeloid sarcoma associated with the CBF beta/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review.ONCOLOGY LETTERS,8(3),1261-1264.
MLA Huang, Bo,et al."Isolated duodenal myeloid sarcoma associated with the CBF beta/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review".ONCOLOGY LETTERS 8.3(2014):1261-1264.
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