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学科主题: 临床医学
题名:
Water channels and zymogen granules in salivary glands
作者: Ishikawa, Y1; Cho, G1; Yuan, ZF1; Skowronski, MT1; Pan, Y1; Ishida, H1
关键词: aquaporin ; lipid raft ; zymogen granule ; supersensitivity ; desensitization
刊名: JOURNAL OF PHARMACOLOGICAL SCIENCES
发表日期: 2006
DOI: 10.1254/jphs.CRJ06007X
卷: 100, 期:5, 页:495-512
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PAROTID ACINAR-CELLS ; PROTEIN-KINASE-C ; INDUCED HETEROLOGOUS DESENSITIZATION ; BETA-ADRENERGIC-RECEPTOR ; RAT SUBMANDIBULAR-GLANDS ; APICAL PLASMA-MEMBRANE ; GPI-ANCHORED PROTEINS ; LIGHT-CHAIN KINASE ; CYCLIC-AMP ; ADENYLYL-CYCLASE
英文摘要:

Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. The molecular mechanisms underlying the secretion of water, a main component of saliva, from salivary glands are not known; the plasma membrane is a major barrier to water transport. A 28-kDa integral membrane protein, distributed in highly water-permeable tissues, was identified as a water channel protein, aquaporin (AQP). Thirteen AQPs (AQPO-AQP12) have been identified in mammals. AQP5 is localized in lipid rafts under unstimulated conditions and translocates to the apical plasma membrane in rat parotid glands upon stimulation by muscarinic agonists. The importance of increases in Intracellular calcium concentration [Ca2+](i) and the nitric oxide synthase and protein kinase G signaling pathway in the translocation of AQP5 is reviewed in section I. Signals generated by the activation of Ca2+ mobilizing receptors simultaneously trigger and regulate exocytosis. Zymogen granule exocytosis occurs under the control of essential process, stimulus-secretion coupling, in salivary glands. Ca2+ signaling is a principal signal in both protein and water secretion from salivary glands induced by cholinergic stimulation. On the other hand, the cyclic adenosine monophosphate (cAMP)/cAMP-dependent protein kinase system has a major role in zymogen granule exocytosis without significant increases in [Ca2+](i). In section II, the mechanisms underlying the control of salivary protein secretion and its dysfunction are reviewed.

语种: 英语
WOS记录号: WOS:000238696400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51684
Appears in Collections:北京大学第一临床医学院_大内科_期刊论文

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作者单位: 1.Univ Tokushima, Sch Dent, Dept Pharmacol, Tokushima 7708504, Japan
2.Univ Tokushima, Sch Dent, Dept Dent Anesthesiol, Tokushima 7708504, Japan
3.Peking Univ, Hosp 1, Dept Internal Med, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Pharmacol, Beijing 100034, Peoples R China
5.Univ Warmia & Mazury, Fac Biol, Dept Anim Physiol, PL-10718 Olsztyn, Poland

Recommended Citation:
Ishikawa, Y,Cho, G,Yuan, ZF,et al. Water channels and zymogen granules in salivary glands[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2006,100(5):495-512.
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