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学科主题: 临床医学
题名:
Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population
作者: Su Yin1; Zhao Yi1; Liu Xu1; Guo Jian-ping1; Jiang Quan3; Liu Xiang-yuan4; Zhang Feng-chun5,6; Zheng Yi7; Li Xiao-xia8; Song Hui9; Huang Ci-bo10; Huang Yan-hong9; Wang Tian11; Pan Si-si1; Li Chun1; Liu Xia1; Zhu Lei1; Zhang Chun-fang2; Li Zhan-guo1
关键词: STAT4 ; systemic lupus erythematosus ; genetic association ; single-nucleotide polymorphisms
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-11-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.22.001
卷: 123, 期:22, 页:3173-3177
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
英文摘要:

Background Recent studies have identified signal transducer and activator of transcription 4 (STAT4) as a susceptibility gene for systemic lupus erythematosus (SLE) in different populations In order to examine whether the allele distribution of the single nucleotide polymorphism (SNP) in gene STAT4 rs7574865 in patients with SLE is different from those of healthy controls in Chinese Northern Han population, we investigated whether the variants of STAT4 rs7574865 were associated with any specific clinical features of SLE

Methods We genotyped SNPs in STAT4 rs7574865 in 252 patients with SLE and 497 healthy controls All subjects were from the Northern part of Chinese Han population The genotypes in rs7574865 were determined by polymerase chain reaction (PCR) and consequence direct sequencing of PCR products in the DNA samples

Results There was a significant difference in distribution of the SNPs in rs7574865 between the SLE patients and healthy controls Compared with healthy controls, there was a significant correlation between TT genotypes in rs7574865 and the risk of SLE when GG genotype was used as a reference genotype after adjusting for gender and age The frequency of T allele in the SLE patients was strongly significantly higher than that of healthy controls Furthermore, there was a significant difference in the distribution of SNP in rs7574865 between male and female SLE patients, when compared with healthy controls The frequency of T allele in rs7574865 in male patients was significantly higher than that of male healthy controls or female patients There was no significant correlation between the frequencies of T allele in STAT4 rs7574865 and the clinical features of SLE

Conclusions The SNP rs7574865 in STAT4 is strongly associated with risk of SLE in the Chinese Northern Han population The TT genotype and T allele in STAT4 rs7574869 are susceptibility factors for SLE, especially for male SLE patients Chin Med J 2010,123(22) 3173-3177

语种: 英语
所属项目编号: 7072085 ; 2006AA02Z495
项目资助者: Beijing Natural Science Foundation ; Chinese National Programs for High Technology Research and Development
WOS记录号: WOS:000284925300001
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51685
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Hosp, Dept Rheumatol & Immunol, Beijing 100730, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Clin Immunol Ctr, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Clin Epidemiol, Beijing 100044, Peoples R China
4.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Rheumatol & Immunol, Beijing 100053, Peoples R China
5.Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing 100191, Peoples R China
6.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Immunol, Beijing 100730, Peoples R China
7.Chinese Acad Med Sci, Beijing 100730, Peoples R China
8.Capital Med Univ, Beijing Chaoyang Hosp, Dept Rheumatol & Immunol, Beijing 100020, Peoples R China
9.Capital Med Univ, Xuanwu Hosp, Dept Rheumatol & Immunol, Beijing 100053, Peoples R China
10.Beijing Jishuitan Hosp, Dept Rheumatol & Immunol, Beijing 100035, Peoples R China
11.Capital Med Univ, Beijing Tongren Hosp, Dept Rheumatol & Immunol, Beijing 100730, Peoples R China

Recommended Citation:
Su Yin,Zhao Yi,Liu Xu,et al. Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population[J]. CHINESE MEDICAL JOURNAL,2010,123(22):3173-3177.
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