IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population
Su Yin1; Zhao Yi1; Liu Xu1; Guo Jian-ping1; Jiang Quan3; Liu Xiang-yuan4; Zhang Feng-chun5,6; Zheng Yi7; Li Xiao-xia8; Song Hui9; Huang Ci-bo10; Huang Yan-hong9; Wang Tian11; Pan Si-si1; Li Chun1; Liu Xia1; Zhu Lei1; Zhang Chun-fang2; Li Zhan-guo1
关键词Stat4 Systemic Lupus Erythematosus Genetic Association Single-nucleotide Polymorphisms
刊名CHINESE MEDICAL JOURNAL
2010-11-20
DOI10.3760/cma.j.issn.0366-6999.2010.22.001
123期:22页:3173-3177
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
英文摘要

Background Recent studies have identified signal transducer and activator of transcription 4 (STAT4) as a susceptibility gene for systemic lupus erythematosus (SLE) in different populations In order to examine whether the allele distribution of the single nucleotide polymorphism (SNP) in gene STAT4 rs7574865 in patients with SLE is different from those of healthy controls in Chinese Northern Han population, we investigated whether the variants of STAT4 rs7574865 were associated with any specific clinical features of SLE

Methods We genotyped SNPs in STAT4 rs7574865 in 252 patients with SLE and 497 healthy controls All subjects were from the Northern part of Chinese Han population The genotypes in rs7574865 were determined by polymerase chain reaction (PCR) and consequence direct sequencing of PCR products in the DNA samples

Results There was a significant difference in distribution of the SNPs in rs7574865 between the SLE patients and healthy controls Compared with healthy controls, there was a significant correlation between TT genotypes in rs7574865 and the risk of SLE when GG genotype was used as a reference genotype after adjusting for gender and age The frequency of T allele in the SLE patients was strongly significantly higher than that of healthy controls Furthermore, there was a significant difference in the distribution of SNP in rs7574865 between male and female SLE patients, when compared with healthy controls The frequency of T allele in rs7574865 in male patients was significantly higher than that of male healthy controls or female patients There was no significant correlation between the frequencies of T allele in STAT4 rs7574865 and the clinical features of SLE

Conclusions The SNP rs7574865 in STAT4 is strongly associated with risk of SLE in the Chinese Northern Han population The TT genotype and T allele in STAT4 rs7574869 are susceptibility factors for SLE, especially for male SLE patients Chin Med J 2010,123(22) 3173-3177

语种英语
WOS记录号WOS:000284925300001
项目编号7072085 ; 2006AA02Z495
资助机构Beijing Natural Science Foundation ; Chinese National Programs for High Technology Research and Development
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51685
专题北京大学第二临床医学院
作者单位1.Beijing Hosp, Dept Rheumatol & Immunol, Beijing 100730, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Clin Immunol Ctr, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Clin Epidemiol, Beijing 100044, Peoples R China
4.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Rheumatol & Immunol, Beijing 100053, Peoples R China
5.Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing 100191, Peoples R China
6.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Immunol, Beijing 100730, Peoples R China
7.Chinese Acad Med Sci, Beijing 100730, Peoples R China
8.Capital Med Univ, Beijing Chaoyang Hosp, Dept Rheumatol & Immunol, Beijing 100020, Peoples R China
9.Capital Med Univ, Xuanwu Hosp, Dept Rheumatol & Immunol, Beijing 100053, Peoples R China
10.Beijing Jishuitan Hosp, Dept Rheumatol & Immunol, Beijing 100035, Peoples R China
11.Capital Med Univ, Beijing Tongren Hosp, Dept Rheumatol & Immunol, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Su Yin,Zhao Yi,Liu Xu,et al. Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population[J]. CHINESE MEDICAL JOURNAL,2010,123(22):3173-3177.
APA Su Yin.,Zhao Yi.,Liu Xu.,Guo Jian-ping.,Jiang Quan.,...&Li Zhan-guo.(2010).Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population.CHINESE MEDICAL JOURNAL,123(22),3173-3177.
MLA Su Yin,et al."Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population".CHINESE MEDICAL JOURNAL 123.22(2010):3173-3177.
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