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Association between copy-number variations of the human histamine H4 receptor gene and atopic dermatitis in a Chinese population
Chen, B.1; Ye, T.1,2,3; Shao, Y.1,2,3; Zhang, J.1,2,3; Zhong, Q.1,2,3; Hu, X.1,2,3; Zhang, W.4; Yu, B.1,2,3
刊名CLINICAL AND EXPERIMENTAL DERMATOLOGY
2013-04-01
DOI10.1111/ced.12117
38期:3页:295-301
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
资助者Pierre Fabre Atopic Dermatitis Foundation Project ; Shenzhen Science and Technology Project ; Pierre Fabre Atopic Dermatitis Foundation Project ; Shenzhen Science and Technology Project
研究领域[WOS]Dermatology
关键词[WOS]H-4 RECEPTOR ; MOLECULAR-CLONING ; CELLS ; POLYMORPHISMS ; EXPRESSION ; IGE
英文摘要

Background Atopic dermatitis (AD) is a chronic, relapsing allergic skin disease. The histamine H4 receptor (HRH4) has been shown to be associated with a number of autoimmune disorders, including AD. Aim To explore a possible association between copy-number variations (CNVs) of the HRH4 gene and the risk of AD in a Chinese population. Methods Genomic DNA and RNA were collected from 541 patients with AD and 613 healthy controls, and the CNVs and mRNA levels of HRH4 were examined. ELISA was used to measure the levels of IgE in all participants. Results Amplifications of HRH4 copy numbers were associated with the risk of developing AD (P<0.05, OR=1.85, 95% CI 1.302.63), whereas deletions of HRH4 copy numbers were not associated with disease risk for AD (P=0.30, OR=0.82, 95% CI 0.571.19). HRH4 mRNA levels were much higher in samples with HRH4 copy-number amplifications than in those without such amplifications (P<0.05). IgE levels were associated with amplifications (P<0.05, OR=1.96, 95% CI 1.193.25), but not with deletions (P=0.63, OR=0.87, 95% CI 0.491.54) of HRH4 copy numbers. Conclusions CNVs of the HRH4 gene are associated with AD in a Chinese population.

语种英语
资助者Pierre Fabre Atopic Dermatitis Foundation Project ; Shenzhen Science and Technology Project ; Pierre Fabre Atopic Dermatitis Foundation Project ; Shenzhen Science and Technology Project
WOS记录号WOS:000316622700013
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51688
专题北京大学深圳医院_皮肤性病科
作者单位1.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen 518036, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen Key Discipline Dermatol, Shenzhen 518036, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen, Peoples R China
4.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China
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GB/T 7714
Chen, B.,Ye, T.,Shao, Y.,et al. Association between copy-number variations of the human histamine H4 receptor gene and atopic dermatitis in a Chinese population[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY,2013,38(3):295-301.
APA Chen, B..,Ye, T..,Shao, Y..,Zhang, J..,Zhong, Q..,...&Yu, B..(2013).Association between copy-number variations of the human histamine H4 receptor gene and atopic dermatitis in a Chinese population.CLINICAL AND EXPERIMENTAL DERMATOLOGY,38(3),295-301.
MLA Chen, B.,et al."Association between copy-number variations of the human histamine H4 receptor gene and atopic dermatitis in a Chinese population".CLINICAL AND EXPERIMENTAL DERMATOLOGY 38.3(2013):295-301.
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