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学科主题: 临床医学
题名:
Crucial role of peroxiredoxin III in placental antioxidant defense of mice
作者: Li, Lianqin1,2; Shoji, Wataru2; Oshima, Hiroaki2; Obinata, Masuo1; Fukumoto, Manabu3; Kanno, Naoko3
关键词: stillbirth ; peroxiredoxin III (PrxIII) ; placenta ; oxidative stress
刊名: FEBS LETTERS
发表日期: 2008-07-09
DOI: 10.1016/j.febslet.2008.05.050
卷: 582, 期:16, 页:2431-2434
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: OXIDATIVE STRESS ; LIPID-PEROXIDATION ; IN-VITRO ; THIOREDOXIN ; EXPRESSION ; PROTEIN ; PREECLAMPSIA ; MITOCHONDRIA ; TISSUES ; CELLS
英文摘要:

We observed frequent stillbirth in peroxiredoxin III (PrxIII) knockout maternal mice. Quantitative real time PCR (qRT-PCR) and Western-blot analysis revealed increased oxidative stress in placentas that were deficient in PrxIII. We did not find significant difference between PrxIII knockout maternal mice and wild-type littermates in hematological parameters, fetal number, and embryonic development. Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice. Our results provided in vivo evidence that PrxIII played a crucial role in placental antioxidant defense. Up-regulation of PrxI might provide a compensation that protected erythrocytes against oxidative damage. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000257864100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51695
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
2.Tohoku Univ, Inst Dev Aging & Canc, Dept Cell Biol, Sendai, Miyagi 9808575, Japan
3.Tohoku Univ, Inst Dev Aging & Canc, Dept Pathol, Sendai, Miyagi 9808575, Japan

Recommended Citation:
Li, Lianqin,Shoji, Wataru,Oshima, Hiroaki,et al. Crucial role of peroxiredoxin III in placental antioxidant defense of mice[J]. FEBS LETTERS,2008,582(16):2431-2434.
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