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Crucial role of peroxiredoxin III in placental antioxidant defense of mice
Li, Lianqin1,2; Shoji, Wataru2; Oshima, Hiroaki2; Obinata, Masuo1; Fukumoto, Manabu3; Kanno, Naoko3
关键词Stillbirth Peroxiredoxin Iii (prxIii) Placenta Oxidative Stress
刊名FEBS LETTERS
2008-07-09
DOI10.1016/j.febslet.2008.05.050
582期:16页:2431-2434
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]OXIDATIVE STRESS ; LIPID-PEROXIDATION ; IN-VITRO ; THIOREDOXIN ; EXPRESSION ; PROTEIN ; PREECLAMPSIA ; MITOCHONDRIA ; TISSUES ; CELLS
英文摘要

We observed frequent stillbirth in peroxiredoxin III (PrxIII) knockout maternal mice. Quantitative real time PCR (qRT-PCR) and Western-blot analysis revealed increased oxidative stress in placentas that were deficient in PrxIII. We did not find significant difference between PrxIII knockout maternal mice and wild-type littermates in hematological parameters, fetal number, and embryonic development. Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice. Our results provided in vivo evidence that PrxIII played a crucial role in placental antioxidant defense. Up-regulation of PrxI might provide a compensation that protected erythrocytes against oxidative damage. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000257864100017
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51695
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
2.Tohoku Univ, Inst Dev Aging & Canc, Dept Cell Biol, Sendai, Miyagi 9808575, Japan
3.Tohoku Univ, Inst Dev Aging & Canc, Dept Pathol, Sendai, Miyagi 9808575, Japan
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GB/T 7714
Li, Lianqin,Shoji, Wataru,Oshima, Hiroaki,et al. Crucial role of peroxiredoxin III in placental antioxidant defense of mice[J]. FEBS LETTERS,2008,582(16):2431-2434.
APA Li, Lianqin,Shoji, Wataru,Oshima, Hiroaki,Obinata, Masuo,Fukumoto, Manabu,&Kanno, Naoko.(2008).Crucial role of peroxiredoxin III in placental antioxidant defense of mice.FEBS LETTERS,582(16),2431-2434.
MLA Li, Lianqin,et al."Crucial role of peroxiredoxin III in placental antioxidant defense of mice".FEBS LETTERS 582.16(2008):2431-2434.
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