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High serum iron level is associated with an increased risk of hypertensive disorders during pregnancy: a meta-analysis of observational studies
Song, Qi-Ying1,2; Luo, Wei-Ping1; Zhang, Cai-Xia1
关键词Serum Iron Pregnancy Hypertension Preeclampsia Eclampsia Meta-analysis
刊名NUTRITION RESEARCH
2015-12-01
DOI10.1016/j.nutres.2015.09.021
35期:12页:1060-1069
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]OXIDATIVE STRESS ; TRACE-ELEMENTS ; PREECLAMPSIA ; WOMEN ; PARAMETERS ; CERULOPLASMIN ; COPPER ; ZINC
英文摘要

The exact cause of hypertensive disorders in pregnancy (HDP) has not been clearly elucidated. Some researchers have recently investigated the relationship between the serum iron level and the incidence of HDP. However, the results are inconsistent, and these data have not been systematically evaluated. Therefore, we conducted a meta-analysis to evaluate the real association between the serum iron level and the incidence of HDP. We searched for published and ongoing trials in PubMed, EMBASE, Scopus, Web of Science, the Chinese Biomedical Database, CNKI, and the WANFANG database from January 1990 to May 2015 to identify studies that met our predefined criteria. Finally, 26 studies, including 1 cross-sectional study, 23 case-control studies, and 2 prospective nested case-control studies, including 1349 patients and 1119 control participants, were selected for this meta-analysis. The pooled results show that a high serum iron level increased the incidence of HDP (standard mean deviation [SMD], 1.50; 95% confidence interval [CI], 0.94-2.06; P < .0001), especially gestational hypertension (SMD, 3.65; 95% CI, 1.50-5.81; P = .0009) and preeclampsia (SMD, 1.27; 95% CI, 0.76-1.78; P < .0001). No significant difference was seen between the eclampsia groups and the control participants (SMD, 3.34; 95% CI, -0.02 to 6.69; P = .05). The results of this meta-analysis indicate that a high serum iron level is associated with an increased risk of HDP, especially gestational hypertension and preeclampsia. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000366883400004
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51700
专题北京大学公共卫生学院
作者单位1.Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Child Adolescent & Womens Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Song, Qi-Ying,Luo, Wei-Ping,Zhang, Cai-Xia. High serum iron level is associated with an increased risk of hypertensive disorders during pregnancy: a meta-analysis of observational studies[J]. NUTRITION RESEARCH,2015,35(12):1060-1069.
APA Song, Qi-Ying,Luo, Wei-Ping,&Zhang, Cai-Xia.(2015).High serum iron level is associated with an increased risk of hypertensive disorders during pregnancy: a meta-analysis of observational studies.NUTRITION RESEARCH,35(12),1060-1069.
MLA Song, Qi-Ying,et al."High serum iron level is associated with an increased risk of hypertensive disorders during pregnancy: a meta-analysis of observational studies".NUTRITION RESEARCH 35.12(2015):1060-1069.
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