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学科主题: 公共卫生
题名:
High serum iron level is associated with an increased risk of hypertensive disorders during pregnancy: a meta-analysis of observational studies
作者: Song, Qi-Ying1,2; Luo, Wei-Ping1; Zhang, Cai-Xia1
关键词: Serum iron ; Pregnancy ; Hypertension ; Preeclampsia ; Eclampsia ; Meta-analysis
刊名: NUTRITION RESEARCH
发表日期: 2015-12-01
DOI: 10.1016/j.nutres.2015.09.021
卷: 35, 期:12, 页:1060-1069
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: OXIDATIVE STRESS ; TRACE-ELEMENTS ; PREECLAMPSIA ; WOMEN ; PARAMETERS ; CERULOPLASMIN ; COPPER ; ZINC
英文摘要:

The exact cause of hypertensive disorders in pregnancy (HDP) has not been clearly elucidated. Some researchers have recently investigated the relationship between the serum iron level and the incidence of HDP. However, the results are inconsistent, and these data have not been systematically evaluated. Therefore, we conducted a meta-analysis to evaluate the real association between the serum iron level and the incidence of HDP. We searched for published and ongoing trials in PubMed, EMBASE, Scopus, Web of Science, the Chinese Biomedical Database, CNKI, and the WANFANG database from January 1990 to May 2015 to identify studies that met our predefined criteria. Finally, 26 studies, including 1 cross-sectional study, 23 case-control studies, and 2 prospective nested case-control studies, including 1349 patients and 1119 control participants, were selected for this meta-analysis. The pooled results show that a high serum iron level increased the incidence of HDP (standard mean deviation [SMD], 1.50; 95% confidence interval [CI], 0.94-2.06; P < .0001), especially gestational hypertension (SMD, 3.65; 95% CI, 1.50-5.81; P = .0009) and preeclampsia (SMD, 1.27; 95% CI, 0.76-1.78; P < .0001). No significant difference was seen between the eclampsia groups and the control participants (SMD, 3.34; 95% CI, -0.02 to 6.69; P = .05). The results of this meta-analysis indicate that a high serum iron level is associated with an increased risk of HDP, especially gestational hypertension and preeclampsia. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: China Nutrition Society of the Maternal and Child Nutrition Branch
WOS记录号: WOS:000366883400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51700
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Child Adolescent & Womens Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Song, Qi-Ying,Luo, Wei-Ping,Zhang, Cai-Xia. High serum iron level is associated with an increased risk of hypertensive disorders during pregnancy: a meta-analysis of observational studies[J]. NUTRITION RESEARCH,2015,35(12):1060-1069.
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