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Determination and pharmacokinetic study of tussilagone in rat plasma by RP-HPLC method
Liu, Yu-Feng1,2; Yang, Xiu-Wei1,2; Lu, Wei3; Xin, Xiu-Lan4
关键词Tussilago Farfara Tussilagone Pharmacokinetics Bioavailability Rp-hplc
刊名BIOMEDICAL CHROMATOGRAPHY
2008-11-01
DOI10.1002/bmc.1042
22期:11页:1194-1200
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
资助者National High Technology Research and Development Program of China ; Beijing Municipal Special-purpose Science Foundation of China ; National High Technology Research and Development Program of China ; Beijing Municipal Special-purpose Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
英文摘要

A simple and rapid high-performance liquid chromatographic method was used to study the pharmacokinetics of tussilagone, one of the main bioactive constituents in the flower buds of Tussilago farfara L. of traditional Chinese medicines, in rat plasma. Plasma was deproteinized by ethyl acetate for sample clean-up. The drugs were separated on a Dikma Diamonsil (TM) C(18) column (4.6 x 250 mm, 5.0 mu m), and detected by UV absorption at 220 nm. Methanol-water (75:25, v/v) was used as the mobile phase. It was applied to the pharmacokinetic study of tussilagone in rats after a dose of 5 mg/kg by intravenous administration and a dose of 200 mg/kg by intragastrical administration. A biphasic phenomenon with a rapid distribution followed by a slower elimination phase was observed from the plasma concentration-time curve by intravenous administration, while the plasma concentration-time curve of tussilagone conformed to a one-compartment model by intragastrical administration. The absolute bioavailability of tussilagone is about 1.31%. Copyright (c) 2008 John Wiley & Sons, Ltd.

语种英语
所属项目编号2002AA2Z343C ; 2004AA2Z3783 ; 2004AA2Z3730-07 ; 2006BA106A01-02 ; Z0004105040311
资助者National High Technology Research and Development Program of China ; Beijing Municipal Special-purpose Science Foundation of China ; National High Technology Research and Development Program of China ; Beijing Municipal Special-purpose Science Foundation of China
WOS记录号WOS:000261262300003
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51702
专题北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
4.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Liu, Yu-Feng,Yang, Xiu-Wei,Lu, Wei,et al. Determination and pharmacokinetic study of tussilagone in rat plasma by RP-HPLC method[J]. BIOMEDICAL CHROMATOGRAPHY,2008,22(11):1194-1200.
APA Liu, Yu-Feng,Yang, Xiu-Wei,Lu, Wei,&Xin, Xiu-Lan.(2008).Determination and pharmacokinetic study of tussilagone in rat plasma by RP-HPLC method.BIOMEDICAL CHROMATOGRAPHY,22(11),1194-1200.
MLA Liu, Yu-Feng,et al."Determination and pharmacokinetic study of tussilagone in rat plasma by RP-HPLC method".BIOMEDICAL CHROMATOGRAPHY 22.11(2008):1194-1200.
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