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学科主题: 药学
题名:
Determination and pharmacokinetic study of tussilagone in rat plasma by RP-HPLC method
作者: Liu, Yu-Feng1,2; Yang, Xiu-Wei1,2; Lu, Wei3; Xin, Xiu-Lan4
关键词: Tussilago farfara ; tussilagone ; pharmacokinetics ; bioavailability ; RP-HPLC
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2008-11-01
DOI: 10.1002/bmc.1042
卷: 22, 期:11, 页:1194-1200
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
英文摘要:

A simple and rapid high-performance liquid chromatographic method was used to study the pharmacokinetics of tussilagone, one of the main bioactive constituents in the flower buds of Tussilago farfara L. of traditional Chinese medicines, in rat plasma. Plasma was deproteinized by ethyl acetate for sample clean-up. The drugs were separated on a Dikma Diamonsil (TM) C(18) column (4.6 x 250 mm, 5.0 mu m), and detected by UV absorption at 220 nm. Methanol-water (75:25, v/v) was used as the mobile phase. It was applied to the pharmacokinetic study of tussilagone in rats after a dose of 5 mg/kg by intravenous administration and a dose of 200 mg/kg by intragastrical administration. A biphasic phenomenon with a rapid distribution followed by a slower elimination phase was observed from the plasma concentration-time curve by intravenous administration, while the plasma concentration-time curve of tussilagone conformed to a one-compartment model by intragastrical administration. The absolute bioavailability of tussilagone is about 1.31%. Copyright (c) 2008 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 2002AA2Z343C ; 2004AA2Z3783 ; 2004AA2Z3730-07 ; 2006BA106A01-02 ; Z0004105040311
项目资助者: National High Technology Research and Development Program of China ; Beijing Municipal Special-purpose Science Foundation of China
WOS记录号: WOS:000261262300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51702
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
4.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China

Recommended Citation:
Liu, Yu-Feng,Yang, Xiu-Wei,Lu, Wei,et al. Determination and pharmacokinetic study of tussilagone in rat plasma by RP-HPLC method[J]. BIOMEDICAL CHROMATOGRAPHY,2008,22(11):1194-1200.
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