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IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-kappa B/S6K signalings
Wu, Wantong1,2,3; Wang, Weiqiang4; Wang, Yun5; Li, Wenwen4; Yu, Gang1,2; Li, Zhonglong1,2; Fang, Chunmin1,2; Shen, Yue1,2; Sun, Zhina1,2; Han, Ling1,2; Yu, Juan1,2; Fang, Lijun1,2; Chen, Song1,2; Dong, Kui4; Han, Zhongchao1,2; Liu, Hanzhi1,2; Luo, Yuechen1,2; Feng, Xiaoming1,2
关键词Il-37b Dendritic Cells Cytokines
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
2015-08-01
DOI10.1093/abbs/gmv058
47期:8页:597-603
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]INTERLEUKIN-1 ; IMMUNITY ; IDENTIFICATION ; MACROPHAGES ; EXPRESSION ; RESPONSES ; RECEPTOR ; COLITIS ; MEMBERS ; FAMILY
英文摘要

Interleukin 37b (IL-37b) plays a key role in suppressing immune responses, partially by modulating the function of dendritic cells (DCs). However, the precise mechanisms are still largely unknown. Here, we investigated the effects of IL-37b on DC maturation and T cell responses induced by DCs, and explored the involved signaling pathways. It was found that IL-37b down-regulated the expressions of co-stimulatory molecules CD80 and CD86 on DCs in vitro. At the same time, the expressions of pro-inflammatory cytokines, such as TNF-alpha and IL-6, were suppressed, while the expression of the T cell inhibitory cytokine TGF-beta was increased in IL-37b-treated DCs. In addition, the activation effect of DCs on T cells was impaired by IL-37b. We further revealed that extracellular single-regulated kinase (ERK), nuclear factor-kappa B (NF-kappa B), and mTOR-S6K signaling pathways were involved in the inhibition of DCs induced by IL-37b. This was confirmed by the similarly suppressive effect of chemical inhibitors against NF-kappa B, ERK, and S6K on the expressions of IL-6 and TNF-a in DCs. In conclusion, these results demonstrated that IL-37b suppressed DC maturation and immunostimulatory capacity in T cell priming by involving in ERK, NF-kappa B, and S6K-based inhibitory signaling pathways.

语种英语
WOS记录号WOS:000359308500004
项目编号2013CB966904 ; 2015CB964402 ; 81273217 ; 81322007 ; 81401295 ; 12JCYBJC32800 ; 20121106120037
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Tianjin Research Program of Application Foundation and Advanced Technology ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; Technology Foundation for Selected Overseas Chinese Scholar ; Recruitment Program of Global Youth Experts
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51709
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Tianjin Dongli Hosp, Tianjin 300300, Peoples R China
2.Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China
3.Chinese Acad Med Sci, Hosp Blood Dis, Tianjin 300020, Peoples R China
4.Tianjin Med Univ, Gen Hosp, Dept Gastroenterol & Hepatol, Tianjin 300052, Peoples R China
5.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
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Wu, Wantong,Wang, Weiqiang,Wang, Yun,et al. IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-kappa B/S6K signalings[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015,47(8):597-603.
APA Wu, Wantong.,Wang, Weiqiang.,Wang, Yun.,Li, Wenwen.,Yu, Gang.,...&Feng, Xiaoming.(2015).IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-kappa B/S6K signalings.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,47(8),597-603.
MLA Wu, Wantong,et al."IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-kappa B/S6K signalings".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47.8(2015):597-603.
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