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The effect of celecoxib on tissue factor expression in pancreatic cancer cells
Wang Hui-Yuan1; Yang Yin-Mo1; Yan, Zhuang1; Chen Huan-Nian1; Wan Yuan-Lian1; Huang Yan-Ting1
关键词Pancreatic Neoplasms Tissuefactor Celecoxib
刊名CHINESE MEDICAL JOURNAL
2007-10-20
120期:20页:1753-1756
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]NF-KAPPA-B ; FACTOR VIIA ; INHIBITOR ; METASTASIS ; MELANOMA ; PATHWAY ; CHEMOPREVENTION ; ADENOCARCINOMA ; COAGULATION ; KINASE
英文摘要

Background Tissue factor (TF) is overexpressed in many malignant tumours and is linked to the pathogenesis and prognosis of such malignancies. In vitro studies have proved that reduced expression of TF has inhibitory effect on the angiogenesis and cell proliferation of the malignant tumour. Therefore, TF suppression has been raised as a possible treatment for malignant tumours. Here we investigated the effect of celecoxib on TF expression induced by tumour necrosis factor a (TNF alpha) in PANC-1 cells and a possible molecular mechanism underlying the celecoxib effect.

Methods Various doses of celecoxib solution were added to standard cell numbers of PANC-1 cells mixed with equal dose of TNFa for 6 hours. The expression of tissue factor was detected quantitatively by Western blot, whilst the activation of nuclear factor kappa B was tested by electromobility shift assay.

Results As the doses of celecoxib increased, the tissue factor expression was decreased in PANC-1 cells and so was the activation of nuclear factor kappa B.

Conclusions Celecoxib can downregulate the expression of tissue factor induced by TNFa in PANC-1 cells. This antitumour effect of celecoxib can be explained indirectly via its suppressive role in activation of nuclear factor kappa B.

语种英语
WOS记录号WOS:000250539800004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51718
专题北京大学第一临床医学院_普通外科
作者单位1.Peking Univ, Dept Gen Surg, Hosp 1, Beijing 100034, Peoples R China
2.Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing 100053, Peoples R China
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Wang Hui-Yuan,Yang Yin-Mo,Yan, Zhuang,et al. The effect of celecoxib on tissue factor expression in pancreatic cancer cells[J]. CHINESE MEDICAL JOURNAL,2007,120(20):1753-1756.
APA Wang Hui-Yuan,Yang Yin-Mo,Yan, Zhuang,Chen Huan-Nian,Wan Yuan-Lian,&Huang Yan-Ting.(2007).The effect of celecoxib on tissue factor expression in pancreatic cancer cells.CHINESE MEDICAL JOURNAL,120(20),1753-1756.
MLA Wang Hui-Yuan,et al."The effect of celecoxib on tissue factor expression in pancreatic cancer cells".CHINESE MEDICAL JOURNAL 120.20(2007):1753-1756.
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