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学科主题: 基础医学
题名:
Suppression of the Production of Transforming Growth Factor beta 1, Interleukin-10, and Vascular Endothelial Growth Factor in the B16F10 Cells by Ganoderma lucidum Polysaccharides
作者: Sun, Li-Xin1; Lin, Zhi-Bin2; Duan, Xin-Suo1; Qi, Hai-Hua1; Yang, Ning1; Li, Min2; Xing, En-Hong1; Sun, Yu1; Yu, Min1; Li, Wei-Dong2; Lu, Jie1
刊名: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
发表日期: 2014-09-01
DOI: 10.1089/jir.2012.0101
卷: 34, 期:9, 页:667-675
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Immunology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]: DENDRITIC CELLS ; TGF-BETA ; COLORECTAL-CANCER ; IMMUNE SUPPRESSION ; IN-VITRO ; CULTURE SUPERNATANTS ; SERUM INTERLEUKIN-10 ; POSSIBLE MECHANISMS ; CYTOKINE RESPONSE ; TUMOR ENVIRONMENT
英文摘要:

Transforming growth factor beta (TGF-beta), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF) are three of the commonly studied cytokines playing an important role in tumor initiation and progression. Besides their promotional effects on tumor progression, the three cytokines have immunosuppressive effects that facilitate tumor initiation and progression as well. Ganoderma lucidum polysaccharides (Gl-PS) with multiple bioactivities may have the effect on B16F10 melanoma cells to induce stronger antitumor immune response that has been demonstrated. Gl-PS may have the suppressive effects on the production of these three cytokines, which has yet to be demonstrated. In this study, we tested these effects of Gl-PS by incubating Gl-PS with malignant tumor cells such as B16F10 cells, a melanoma cell line, and LA795 cells, a lung carcinoma cell line. RT-qPCR and enzyme-linked immunosorbent assay showed that the production of TGF-beta 1, IL-10, and VEGF in B16F10 melanoma cells and LA795 lung carcinoma cells was suppressed by Gl-PS at both mRNA and protein levels, suggesting that the suppression on production of TGF-beta, IL-10, and VEGF in B16F10 melanoma cells and LA795 lung carcinoma cells by Gl-PS may contribute to the therapy on melanoma and lung carcinoma along with the induction of stronger antitumor immune response.

语种: 英语
WOS记录号: WOS:000341662400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51720
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Chengde Med Coll, Affiliated Hosp, Chengde 067000, Hebei Province, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Li-Xin,Lin, Zhi-Bin,Duan, Xin-Suo,et al. Suppression of the Production of Transforming Growth Factor beta 1, Interleukin-10, and Vascular Endothelial Growth Factor in the B16F10 Cells by Ganoderma lucidum Polysaccharides[J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,2014,34(9):667-675.
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