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学科主题: 临床医学
题名:
Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages
作者: Wang, Yi1; Sun, Wei1; Cao, Guang1; Meng, Liang1; Song, Laifeng1; Du, Xiangke1
关键词: nonreperfusion ; reperfusion ; magnetic resonance imaging ; myocardial infarction ; delayed hyperenhancement
刊名: JOURNAL OF MAGNETIC RESONANCE IMAGING
发表日期: 2006-10-01
DOI: 10.1002/jmri.20710
卷: 24, 期:4, 页:851-857
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: CORONARY-ARTERY OCCLUSION ; GD-DTPA ; PARTITION-COEFFICIENT ; CONTRAST ENHANCEMENT ; IRREVERSIBLE INJURY ; EXTENT ; MRI ; VIABILITY ; ISCHEMIA ; REFLECT
英文摘要:

Purpose: To investigate delayed hyperenhancement during different healing stages of myocardial infarct with and without reperfusion in a pig model.

Materials and Methods: Twelve pigs were studied. Six pigs were subjected to permanent right coronary artery (RCA) occlusion, and the other six were subjected to transient 90-minute RCA occlusion. In vivo MRI including first-pass perfusion and myocardial delayed enhancement (MDE) was performed at four, eight, 12, and 24 hours, and eight days after the artery occlusion. The MDE scan was repeated four times, two to 32 minutes after contrast administration.

Results: For all six pigs with reperfusion, the four-hour MRI showed transmural perfusion defect and no delayed hyperenhancement; from eight hours on, delayed hyperenhancement appeared and its spatial extent gradually increased until it became transmural hyperenhancement at eight days. However, in all six pigs with reperfusion, hyperenhancement was present at every stage from four hours to eight days. Pathology confirmed the existence of infarct at various stages of healing irrespective of reperfusion status.

Conclusion: Occlusive hyperactive infarct did not exhibit any delayed hyperenhancement, which indicates that perfusion plays an important role in delayed enhancement at the hyperacute stage.

语种: 英语
WOS记录号: WOS:000240882000016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51724
Appears in Collections:北京大学第二临床医学院_放射科_期刊论文

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作者单位: 1.GE Healthcare Great China, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China
3.Beijing Fuwai Hosp, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Wang, Yi,Sun, Wei,Cao, Guang,et al. Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2006,24(4):851-857.
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