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学科主题: 临床医学
题名:
Prophylactic Intravesical Chemotherapy to Prevent Bladder Tumors after Nephroureterectomy for Primary Upper Urinary Tract Urothelial Carcinomas: A Systematic Review and Meta-Analysis
作者: Fang, Dong; Li, Xue-Song; Xiong, Geng-Yan; Yao, Lin; He, Zhi-Song; Zhou, Li-Qun
关键词: Bladder cancer ; Intravesical chemotherapy ; Meta-analysis ; Nephroureterectomy ; Upper urinary tract urothelial carcinoma
刊名: UROLOGIA INTERNATIONALIS
发表日期: 2013
DOI: 10.1159/000350508
卷: 91, 期:3, 页:291-296
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: TRANSITIONAL-CELL-CARCINOMA ; RANDOMIZED CLINICAL-TRIALS ; PROGNOSTIC-FACTORS ; RISK-FACTORS ; MITOMYCIN-C ; CANCER ; RECURRENCE ; INSTILLATION ; MANAGEMENT ; SURVIVAL
英文摘要:

Introduction: Intravesical recurrence after treatment of primary upper urinary tract urothelial carcinomas (UUT-UCs) is common. While intravesical instillation is widely used to prevent recurrence after transurethral resection for primary bladder tumors, there is still no consensus on the prophylactic capability of intravesical chemotherapy in preventing bladder tumor recurrence after surgery for UUT-UCs. Methods: A meta-analysis of the published results of clinical trials was performed to compare radical surgery alone or surgery plus postoperative intravesical chemotherapy. The primary end point was to determine the percentage of patients with recurrence in the different groups. Results: Our study includes five trials with recurrence information on 614 patients. During follow-up, 55 of 268 (20.5%) patients who received postoperative instillation had bladder recurrence compared to 127 of 346 (36.7%) patients who had no adjuvant treatment a decrease of 41% in the odds of recurrence with chemotherapy (odds ratio 0.48, 95% confidence interval 0.33-0.69, p = 0.0001). No serious adverse events were reported. Subgroup analyses were temporarily unavailable. Conclusions: Postoperative intravesical chemotherapy significantly decreases the risk of bladder recurrence after nephroureterectomy for primary UUT-UCs. Postoperative intravesical instillation is considered the treatment of choice after nephroureterectomy. (C) 2013 S. Karger AG, Basel

语种: 英语
WOS记录号: WOS:000325832600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51725
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Urol, Inst Urol,Natl Res Ctr Urol Canc, Beijing 100034, Peoples R China

Recommended Citation:
Fang, Dong,Li, Xue-Song,Xiong, Geng-Yan,et al. Prophylactic Intravesical Chemotherapy to Prevent Bladder Tumors after Nephroureterectomy for Primary Upper Urinary Tract Urothelial Carcinomas: A Systematic Review and Meta-Analysis[J]. UROLOGIA INTERNATIONALIS,2013,91(3):291-296.
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