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Prophylactic Intravesical Chemotherapy to Prevent Bladder Tumors after Nephroureterectomy for Primary Upper Urinary Tract Urothelial Carcinomas: A Systematic Review and Meta-Analysis
Fang, Dong; Li, Xue-Song; Xiong, Geng-Yan; Yao, Lin; He, Zhi-Song; Zhou, Li-Qun
关键词Bladder Cancer Intravesical Chemotherapy Meta-analysis Nephroureterectomy Upper Urinary Tract Urothelial Carcinoma
刊名UROLOGIA INTERNATIONALIS
2013
DOI10.1159/000350508
91期:3页:291-296
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]TRANSITIONAL-CELL-CARCINOMA ; RANDOMIZED CLINICAL-TRIALS ; PROGNOSTIC-FACTORS ; RISK-FACTORS ; MITOMYCIN-C ; CANCER ; RECURRENCE ; INSTILLATION ; MANAGEMENT ; SURVIVAL
英文摘要

Introduction: Intravesical recurrence after treatment of primary upper urinary tract urothelial carcinomas (UUT-UCs) is common. While intravesical instillation is widely used to prevent recurrence after transurethral resection for primary bladder tumors, there is still no consensus on the prophylactic capability of intravesical chemotherapy in preventing bladder tumor recurrence after surgery for UUT-UCs. Methods: A meta-analysis of the published results of clinical trials was performed to compare radical surgery alone or surgery plus postoperative intravesical chemotherapy. The primary end point was to determine the percentage of patients with recurrence in the different groups. Results: Our study includes five trials with recurrence information on 614 patients. During follow-up, 55 of 268 (20.5%) patients who received postoperative instillation had bladder recurrence compared to 127 of 346 (36.7%) patients who had no adjuvant treatment a decrease of 41% in the odds of recurrence with chemotherapy (odds ratio 0.48, 95% confidence interval 0.33-0.69, p = 0.0001). No serious adverse events were reported. Subgroup analyses were temporarily unavailable. Conclusions: Postoperative intravesical chemotherapy significantly decreases the risk of bladder recurrence after nephroureterectomy for primary UUT-UCs. Postoperative intravesical instillation is considered the treatment of choice after nephroureterectomy. (C) 2013 S. Karger AG, Basel

语种英语
WOS记录号WOS:000325832600008
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51725
专题北京大学第一临床医学院_泌尿外科
作者单位Peking Univ, Hosp 1, Dept Urol, Inst Urol,Natl Res Ctr Urol Canc, Beijing 100034, Peoples R China
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GB/T 7714
Fang, Dong,Li, Xue-Song,Xiong, Geng-Yan,et al. Prophylactic Intravesical Chemotherapy to Prevent Bladder Tumors after Nephroureterectomy for Primary Upper Urinary Tract Urothelial Carcinomas: A Systematic Review and Meta-Analysis[J]. UROLOGIA INTERNATIONALIS,2013,91(3):291-296.
APA Fang, Dong,Li, Xue-Song,Xiong, Geng-Yan,Yao, Lin,He, Zhi-Song,&Zhou, Li-Qun.(2013).Prophylactic Intravesical Chemotherapy to Prevent Bladder Tumors after Nephroureterectomy for Primary Upper Urinary Tract Urothelial Carcinomas: A Systematic Review and Meta-Analysis.UROLOGIA INTERNATIONALIS,91(3),291-296.
MLA Fang, Dong,et al."Prophylactic Intravesical Chemotherapy to Prevent Bladder Tumors after Nephroureterectomy for Primary Upper Urinary Tract Urothelial Carcinomas: A Systematic Review and Meta-Analysis".UROLOGIA INTERNATIONALIS 91.3(2013):291-296.
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