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Flavanoids from the stems of Aquilaria sinensis
Chen Dong; Bi Dan; Song Yue-Lin; Tu Peng-Fei
关键词Aquilaria Sinensis Chemical Constituents Flavonoids No
刊名CHINESE JOURNAL OF NATURAL MEDICINES
2012-07-01
DOI10.3724/SP.J.1009.2012.00287
10期:4页:287-291
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Integrative & Complementary Medicine ; Pharmacology & Pharmacy
关键词[WOS]NITRIC-OXIDE
英文摘要

AIM: To study the chemical constituents from the stems of Aquilaria sinensis (Lour.) Gilg. METHODS: Chromatographic separations of silica gel, Sephadex LH-20 and prep-HPLC were used. All the structures were elucidated on the basis of chemical and spectroscopic analysis. RESULTS: Twelve flavonoids were isolated and their structures were identified as aquilarinoside AI (1), lethedioside A (2), 7, 4′-dimethylapigenin-5-O-xylosylglucoside (3), lethedoside A (4), 7-hydroxyl-4′-methyl-5-O- glucosideflavonoid (5), 7, 3′-dimethyl-4′-hydroxyl-5-O-glucosideflavonoide (6), 7, 4′-dimethyl-5-O-glucosideflavonoide (7), 5-hydroxyl-7, 4′-dimethoxyflavone (8), luteolin-7, 3′, 4′-trimethyl (9), hydroxylgenkwanin (10), 5, 7-dihydroxyl-4′-methoxyflavone (11), and formononetin (12). CONCLUSION: Compound 1 is a new flavone glycoside, and compounds 2, 4-7 were isolated from genus Aquilaria sinensis for the first time. 5-O-glycosylflavones 1-7 showed inhibitory activity for nitric oxide (NO) production by activated RAW 264.7 cells.

语种英语
WOS记录号WOS:000306300200010
项目编号2009ZX311-004 ; 2009ZX0308-004
资助机构Ministry of Science and Technology, China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51726
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100101, Peoples R China
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GB/T 7714
Chen Dong,Bi Dan,Song Yue-Lin,et al. Flavanoids from the stems of Aquilaria sinensis[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(4):287-291.
APA Chen Dong,Bi Dan,Song Yue-Lin,&Tu Peng-Fei.(2012).Flavanoids from the stems of Aquilaria sinensis.CHINESE JOURNAL OF NATURAL MEDICINES,10(4),287-291.
MLA Chen Dong,et al."Flavanoids from the stems of Aquilaria sinensis".CHINESE JOURNAL OF NATURAL MEDICINES 10.4(2012):287-291.
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