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学科主题: 药学
题名:
A concise formal synthesis of unnatural (+)-aphanorphine from (2S,4R)-4-hydroxyproline
作者: Ma, Zhiqiang1; Zhai, Hongbin1
关键词: aphanorphine ; configuration inversion ; intramolecular Friedel-Crafts ; marine alkaloid ; synthesis
刊名: SYNLETT
发表日期: 2007-01-04
DOI: 10.1055/s-2006-956499
期: 1, 页:161-163
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: EFFICIENT ASYMMETRIC-SYNTHESIS ; BENZYLIC QUATERNARY CARBONS ; (-)-APHANORPHINE ; APHANORPHINE ; ROUTE ; (+/-)-APHANORPHINE ; INTERMEDIATE ; CONSTRUCTION
英文摘要:

(-)-Aphanorphine methyl ether was synthesized in ten steps from commercially available (2S,4R)-4-hydroxyproline, featuring the C-2 configuration inversion of an intermediate amide and intramolecular Friedel-Crafts reaction. The present work constitutes a formal synthesis of unnatural (+)-aphanorphine.

语种: 英语
WOS记录号: WOS:000244257400034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51735
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Synthet Organ Chem, Shanghai 200032, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Ma, Zhiqiang,Zhai, Hongbin. A concise formal synthesis of unnatural (+)-aphanorphine from (2S,4R)-4-hydroxyproline[J]. SYNLETT,2007(1):161-163.
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