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学科主题: 临床医学
题名:
Modified donor lymphocyte infusion after HLA-mismatched/haploidentical T cell-replete hematopoietic stem cell transplantation for prophylaxis of relapse of leukemia in patients with advanced leukemia
作者: Huang, Xiao-Jun; Liu, Dai-Hong; Liu, Kai-Yan; Xu, Lan-Ping; Chen, Yu-Hong; Wang, Yu; Han, Wei; Chen, Huan
关键词: donor lymphocyte infusion ; HLA-mismatched ; transplantation ; haploidentical ; HSCT ; GVHD ; relapse ; DLI
刊名: JOURNAL OF CLINICAL IMMUNOLOGY
发表日期: 2008-05-01
DOI: 10.1007/s10875-007-9166-z
卷: 28, 期:3, 页:276-283
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; VERSUS-HOST-DISEASE ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; COLONY-STIMULATING FACTOR ; BLOOD PROGENITOR CELLS ; HEMATOLOGICAL MALIGNANCIES ; CHEMOTHERAPY ; THERAPY
英文摘要:

We evaluated the safety and efficacy of donor lymphocyte infusion (DLI) with granulocyte colony-stimulating factor priming and short-term immumosuppressive agents for prophylaxis of relapse in patients with advanced leukemia after human leukocyte antigen (HLA)-mismatched T cell-replete hematopoietic stem cell transplantation (HCT). Twenty-nine patients received prophylactic DLI at a median 75 (33-120) days after HCT. Acute graft-vs-host disease (GVHD) grades 3-4 occurred in six patients, and all cases were controlled. Eleven patients were alive and relapse-free with a probability of leukemia-free survival (LFS) of 37.3 +/- 9.6% at 3 years. Chronic GVHD was associated with a lower relapse rate and higher probability of LFS. Prophylactic-modified DLI is feasible in patients with advanced leukemia to prevent relapse after HLA-mismatched HCT.

语种: 英语
WOS记录号: WOS:000255956500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51737
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Huang, Xiao-Jun,Liu, Dai-Hong,Liu, Kai-Yan,et al. Modified donor lymphocyte infusion after HLA-mismatched/haploidentical T cell-replete hematopoietic stem cell transplantation for prophylaxis of relapse of leukemia in patients with advanced leukemia[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2008,28(3):276-283.
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