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Salusins promote cardiomyocyte growth but does not affect cardiac function in rats
Yu, F1; Zhao, J1; Yang, JH1; Gen, B1; Wang, SH1; Feng, XH1; Tang, CS1; Chang, L1
关键词Salusin Rat Cardiac Function Cardiomyocyte
刊名REGULATORY PEPTIDES
2004-11-15
DOI10.1016/j.regpep.2004.06.013
122期:3页:191-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Physiology
研究领域[WOS]Endocrinology & Metabolism ; Physiology
关键词[WOS]CELLS ; CALCINEURIN ; HYPERTROPHY
英文摘要

Salusin-alpha and -beta are newly found polypeptides that stimulate proliferation, hypotension and bradycardia in vascular smooth muscle cells (VSMCs) and fibroblasts. Propresalusin mRNA is widespread, and positive stains for salusins have been observed in many human tissues such as endothelium and ventricular tissue. To investigate the bio-effect of salusins on cardiovascular function, 20 nmol/kg salusin-alpha or 2 nmol/kg salusin-beta was intravenously (i.v.) injected into rats, and isolated rat hearts were perfused with 10(-12) to 10(-7) mol/l salusin-alpha or -beta. Ca-45(2+) uptake and H-3-Leucine incorporation were determined in Cultured neonatal rat cardiomyocytes. Neither salusin-a nor beta- affected cardiac function in vivo or in vitro but salusin-beta decreased mean arterial blood pressure (MAP). The polypeptides′ stimulation of Ca-45(2+) uptake and H-3-Leucine incorporation was concentration-dependent, and the incorporation was inhibited by nicardipine (Nic) and FK-506 [FK-, an inhibitor of calcineurin (CaN)]. PD98059 [PD; inhibitor of mitogen-activated protein kinase (MAPK)] and chelerythrine [inhibitor of protein kinase C (PKC)] inhibited salusin-stimulated H-3-Leucine incorporation. Endothelin-1 (ET) synergistically increased salusin-induced Ca-45(2+) uptake. Our results suggest that salusin-alpha and -beta did not directly affect cardiac function in the rat heart but that they improved calcium uptake and protein synthesis in neonatal rat cardiomyocytes through the calcium, calcineurin, MAPK and PKC signal pathways. Salusins may be regulatory factors for myocardial growth and hypertrophy. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000225083800008
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51739
专题北京大学第一临床医学院_心血管内科
北京大学医学部管理机构_医学部
北京大学第二临床医学院_肾内科
作者单位1.Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100034, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Dept Physiol, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Echo Lab Cardiol, Beijing 100083, Peoples R China
4.Minist Hlth China, Key Lab Cardiovasc Mol Biol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yu, F,Zhao, J,Yang, JH,et al. Salusins promote cardiomyocyte growth but does not affect cardiac function in rats[J]. REGULATORY PEPTIDES,2004,122(3):191-197.
APA Yu, F.,Zhao, J.,Yang, JH.,Gen, B.,Wang, SH.,...&Chang, L.(2004).Salusins promote cardiomyocyte growth but does not affect cardiac function in rats.REGULATORY PEPTIDES,122(3),191-197.
MLA Yu, F,et al."Salusins promote cardiomyocyte growth but does not affect cardiac function in rats".REGULATORY PEPTIDES 122.3(2004):191-197.
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