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学科主题: 临床医学
题名:
Salusins promote cardiomyocyte growth but does not affect cardiac function in rats
作者: Yu, F1; Zhao, J1; Yang, JH1; Gen, B1; Wang, SH1; Feng, XH1; Tang, CS1; Chang, L1
关键词: salusin ; rat ; cardiac function ; cardiomyocyte
刊名: REGULATORY PEPTIDES
发表日期: 2004-11-15
DOI: 10.1016/j.regpep.2004.06.013
卷: 122, 期:3, 页:191-197
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Physiology
研究领域[WOS]: Endocrinology & Metabolism ; Physiology
关键词[WOS]: CELLS ; CALCINEURIN ; HYPERTROPHY
英文摘要:

Salusin-alpha and -beta are newly found polypeptides that stimulate proliferation, hypotension and bradycardia in vascular smooth muscle cells (VSMCs) and fibroblasts. Propresalusin mRNA is widespread, and positive stains for salusins have been observed in many human tissues such as endothelium and ventricular tissue. To investigate the bio-effect of salusins on cardiovascular function, 20 nmol/kg salusin-alpha or 2 nmol/kg salusin-beta was intravenously (i.v.) injected into rats, and isolated rat hearts were perfused with 10(-12) to 10(-7) mol/l salusin-alpha or -beta. Ca-45(2+) uptake and H-3-Leucine incorporation were determined in Cultured neonatal rat cardiomyocytes. Neither salusin-a nor beta- affected cardiac function in vivo or in vitro but salusin-beta decreased mean arterial blood pressure (MAP). The polypeptides′ stimulation of Ca-45(2+) uptake and H-3-Leucine incorporation was concentration-dependent, and the incorporation was inhibited by nicardipine (Nic) and FK-506 [FK-, an inhibitor of calcineurin (CaN)]. PD98059 [PD; inhibitor of mitogen-activated protein kinase (MAPK)] and chelerythrine [inhibitor of protein kinase C (PKC)] inhibited salusin-stimulated H-3-Leucine incorporation. Endothelin-1 (ET) synergistically increased salusin-induced Ca-45(2+) uptake. Our results suggest that salusin-alpha and -beta did not directly affect cardiac function in the rat heart but that they improved calcium uptake and protein synthesis in neonatal rat cardiomyocytes through the calcium, calcineurin, MAPK and PKC signal pathways. Salusins may be regulatory factors for myocardial growth and hypertrophy. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000225083800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51739
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100034, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Dept Physiol, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Echo Lab Cardiol, Beijing 100083, Peoples R China
4.Minist Hlth China, Key Lab Cardiovasc Mol Biol, Beijing 100083, Peoples R China

Recommended Citation:
Yu, F,Zhao, J,Yang, JH,et al. Salusins promote cardiomyocyte growth but does not affect cardiac function in rats[J]. REGULATORY PEPTIDES,2004,122(3):191-197.
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