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学科主题: 药学
题名:
Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction
作者: Shi, Wan-Lu1,2; Zhao, Xin1,2; Liu, Zhi-Min3; Zhang, Min3; Zhou, Bing-Ying1,2; Pu, Xiao-Ping1,2
关键词: Methamphetamine ; Addiction ; Human serum ; Two-dimensional gel electrophoresis ; Conditioned place preference ; Complement factor H
刊名: NEUROSCIENCE LETTERS
发表日期: 2012-09-06
DOI: 10.1016/j.neulet.2012.07.026
卷: 525, 期:1, 页:23-28
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DISEASE ; METABOLISM
英文摘要:

Methamphetamine (METH) is a new type of drug with strong tolerance and addiction. However, the molecular mechanisms underlying the processes of METH addiction are still not fully understood. To determine possible biomarkers and mechanisms that are responsible for METH addiction, a 2-DE based proteomics approach was used to evaluate the changes in protein expression of the serum in Chinese patients addicted to METH, which to the best of our knowledge is the first study of its kind. We identified five proteins that were markedly altered and complement factor H (CFH), the most stably up-expressed protein in each 2-DE experiment, was further studied using the rat conditioned place preference (CPP) model to detect any changes to its expression in the sera and six brain regions of interest. We report, for the first time, that CFH was positive related to METH addiction. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009CB522007
项目资助者: Research Fund of the State Key Laboratory of Natural and Biomimetic Drugs, Peking University, People&prime ; s Republic of China ; National Basic Research Program of China
WOS记录号: WOS:000308520900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51743
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Shi, Wan-Lu,Zhao, Xin,Liu, Zhi-Min,et al. Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction[J]. NEUROSCIENCE LETTERS,2012,525(1):23-28.
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