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学科主题: 临床医学
题名:
The overlap of corticobasal degeneration and Alzheimer changes: An autopsy case
作者: Zhang, Wei; Zheng, Riliang; Wang, Zhaoxia; Yuan, Yun
关键词: Alzheimer disease ; cortical basal degeneration ; dementia ; parkinsonism ; tauopathy
刊名: NEUROPATHOLOGY
发表日期: 2009-12-01
DOI: 10.1111/j.1440-1789.2009.01012.x
卷: 29, 期:6, 页:720-726
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Pathology
研究领域[WOS]: Neurosciences & Neurology ; Pathology
关键词[WOS]: PROGRESSIVE NONFLUENT APHASIA ; LEWY BODY DISEASE ; PARKINSONS-DISEASE ; PATHOLOGY ; DEMENTIA ; CRITERIA ; TAUOPATHIES ; BRAIN ; TAU
英文摘要:

The aspects of various neurodegenerative diseases can be observed overlapping with each other during autopsy. Corticobasal degeneration (CBD) is a rare neurodegenerative disease, whereas Alzheimer disease (AD) is the most common cause of dementia. In this article, we present the combination of CBD and AD in an autopsy case. The patient, an 82-year-old right-handed woman developed asymmetrical parkinsonism, visuospatial dysfunction and memory loss, as well as subsequent non-influent aphasia over the past 10 years. The autopsy revealed characteristic CBD-related pathology, ballooned neurons, globose tangles and astrocytic plaques, mainly in the frontal cortex and basal ganglia. The Alzheimer-related pathology was also present concomitantly. Senile plagues deposited diffusively throughout the hippocampus and neocortices. Neurofibrillary tangles (NFTs) were more confined to the hippocampus. The autopsy demonstrated pathological overlap of CBD and AD, which therefore explained the clinical early development of dementia and parkinsonism. We should suspect the concurrence of various neurodegenerative disorders in any case with atypical or complex clinical manifestations. Tau pathology is a prominent feature in both CBD and AD. Such a combination would be a clue for the pathogenesis of various tauopathies.

语种: 英语
WOS记录号: WOS:000271713800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51745
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Wei,Zheng, Riliang,Wang, Zhaoxia,et al. The overlap of corticobasal degeneration and Alzheimer changes: An autopsy case[J]. NEUROPATHOLOGY,2009,29(6):720-726.
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