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Protective Immunity Transferred by Infusion of Cytomegalovirus-Specific CD8(+) T Cells within Donor Grafts: Its Associations with Cytomegalovirus Reactivation Following Unmanipulated Allogeneic Hematopoietic Stem Cell Transplantation
Luo, Xiao-Hua2; Huang, Xiao-Jun1; Liu, Kai-Yan1; Xu, Lan-Ping1; Liu, Dai-Hong1
关键词Allogeneic Hematopoietic Stem Cell Transplantation Cmv Reactivation Antigen-specific Ctl Donor Grafts
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2010-07-01
DOI10.1016/j.bbmt.2010.02.007
16期:7页:994-1004
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; SUPERIOR ANTITUMOR IMMUNITY ; CENTRAL MEMORY ; CMV INFECTION ; PROPHYLACTIC INFUSION ; PREEMPTIVE THERAPY ; EFFECTOR MEMORY ; VIRAL-INFECTION ; DENDRITIC CELLS
英文摘要

Human cytomegalovirus (CMV)-specific cytotoxic T lymphocyte (CTL) immune response must be reconstituted for long-term protection against CMV relapse and disease in hematopoietic stem cell transplantation (HSCT) recipients. We phenotypically quantitated absolute numbers of CMV-pp65 peptide-specific CTLs (CTLcmv) in 50 related donor unmanipulated allografts infused into HLA-matched or-mismatched recipients and examined the incidence of CMV reactivation. High CTLcmv with terminally differentiated effector CD45RO(-)CD62L(-) cell (T-EMRA) phenotype in the allografts were associated with reduced risk of CMV reactivation, in the presence of sufficient CD45RO(+)CD62L(-) cell (T-EM) infusion (>= 0.208 x 10(6)/kg). Early after transplantation, there was significant expansion of CTLcmv with the central memory CD45RO(+)CD62L(+) cell (T-CM) phenotype when CMV was reactivated. The frequencies of CTLcmv T-Naive (CD45RO(-)CD62L(+)), T-CM, and T-EM at day 90 posttransplantation and of CTLcmv T-EMRA at day 60 posttransplantation were greater in recipients with higher infusions of CTLCMV T-EMRA, suggesting protective immunity transferred by infusion of CTLcmv within allografts. Moreover, the majority of the CTLcmv identified in the recipients early after HSCT was of donor origin. Our findings support that measuring levels of CTLCMV and its subsets in the donor grafts and manipulating these cells early after transplantation may help control CMV reactivation, which is closely correlated with immune reconstitution and differentiation of CTLcmv subsets. Biol Blood Marrow Transplant 16: 994-1004 (2010) (C) 2010 American Society for Blood and Marrow Transplantation

语种英语
WOS记录号WOS:000279367500012
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51747
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Chongqing Med Univ, Childrens Hosp, Dept Oncohaematol, Chongqing, Peoples R China
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GB/T 7714
Luo, Xiao-Hua,Huang, Xiao-Jun,Liu, Kai-Yan,et al. Protective Immunity Transferred by Infusion of Cytomegalovirus-Specific CD8(+) T Cells within Donor Grafts: Its Associations with Cytomegalovirus Reactivation Following Unmanipulated Allogeneic Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2010,16(7):994-1004.
APA Luo, Xiao-Hua,Huang, Xiao-Jun,Liu, Kai-Yan,Xu, Lan-Ping,&Liu, Dai-Hong.(2010).Protective Immunity Transferred by Infusion of Cytomegalovirus-Specific CD8(+) T Cells within Donor Grafts: Its Associations with Cytomegalovirus Reactivation Following Unmanipulated Allogeneic Hematopoietic Stem Cell Transplantation.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,16(7),994-1004.
MLA Luo, Xiao-Hua,et al."Protective Immunity Transferred by Infusion of Cytomegalovirus-Specific CD8(+) T Cells within Donor Grafts: Its Associations with Cytomegalovirus Reactivation Following Unmanipulated Allogeneic Hematopoietic Stem Cell Transplantation".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 16.7(2010):994-1004.
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