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学科主题: 临床医学
题名:
Protective Immunity Transferred by Infusion of Cytomegalovirus-Specific CD8(+) T Cells within Donor Grafts: Its Associations with Cytomegalovirus Reactivation Following Unmanipulated Allogeneic Hematopoietic Stem Cell Transplantation
作者: Luo, Xiao-Hua2; Huang, Xiao-Jun1; Liu, Kai-Yan1; Xu, Lan-Ping1; Liu, Dai-Hong1
关键词: Allogeneic hematopoietic stem cell transplantation ; CMV reactivation ; Antigen-specific CTL ; Donor grafts
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2010-07-01
DOI: 10.1016/j.bbmt.2010.02.007
卷: 16, 期:7, 页:994-1004
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; SUPERIOR ANTITUMOR IMMUNITY ; CENTRAL MEMORY ; CMV INFECTION ; PROPHYLACTIC INFUSION ; PREEMPTIVE THERAPY ; EFFECTOR MEMORY ; VIRAL-INFECTION ; DENDRITIC CELLS
英文摘要:

Human cytomegalovirus (CMV)-specific cytotoxic T lymphocyte (CTL) immune response must be reconstituted for long-term protection against CMV relapse and disease in hematopoietic stem cell transplantation (HSCT) recipients. We phenotypically quantitated absolute numbers of CMV-pp65 peptide-specific CTLs (CTLcmv) in 50 related donor unmanipulated allografts infused into HLA-matched or-mismatched recipients and examined the incidence of CMV reactivation. High CTLcmv with terminally differentiated effector CD45RO(-)CD62L(-) cell (T-EMRA) phenotype in the allografts were associated with reduced risk of CMV reactivation, in the presence of sufficient CD45RO(+)CD62L(-) cell (T-EM) infusion (>= 0.208 x 10(6)/kg). Early after transplantation, there was significant expansion of CTLcmv with the central memory CD45RO(+)CD62L(+) cell (T-CM) phenotype when CMV was reactivated. The frequencies of CTLcmv T-Naive (CD45RO(-)CD62L(+)), T-CM, and T-EM at day 90 posttransplantation and of CTLcmv T-EMRA at day 60 posttransplantation were greater in recipients with higher infusions of CTLCMV T-EMRA, suggesting protective immunity transferred by infusion of CTLcmv within allografts. Moreover, the majority of the CTLcmv identified in the recipients early after HSCT was of donor origin. Our findings support that measuring levels of CTLCMV and its subsets in the donor grafts and manipulating these cells early after transplantation may help control CMV reactivation, which is closely correlated with immune reconstitution and differentiation of CTLcmv subsets. Biol Blood Marrow Transplant 16: 994-1004 (2010) (C) 2010 American Society for Blood and Marrow Transplantation

语种: 英语
WOS记录号: WOS:000279367500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51747
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Chongqing Med Univ, Childrens Hosp, Dept Oncohaematol, Chongqing, Peoples R China

Recommended Citation:
Luo, Xiao-Hua,Huang, Xiao-Jun,Liu, Kai-Yan,et al. Protective Immunity Transferred by Infusion of Cytomegalovirus-Specific CD8(+) T Cells within Donor Grafts: Its Associations with Cytomegalovirus Reactivation Following Unmanipulated Allogeneic Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2010,16(7):994-1004.
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